Abstract
Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.
Original language | English |
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Pages (from-to) | 815-818 |
Number of pages | 4 |
Journal | Current Neuropharmacology |
Volume | 13 |
Issue number | 6 |
Publication status | Published - 2015 |
Keywords
- Cocaine dependence
- Gamma-aminobutyric acid neurotransmission
- Glutamatergic neurotransmission
- Topiramate
ASJC Scopus subject areas
- Clinical Neurology
- Pharmacology (medical)
- Pharmacology
- Neurology
- Psychiatry and Mental health