The role of topiramate in the management of cocaine addiction: A possible therapeutic option

Antonio Siniscalchi; Antonello Bonci; Nicola Biagio Mercuri; Domenico Pirritano; Aida Squillace; Giovambattista De Sarro; Luca Gallelli

The role of topiramate in the management of cocaine addiction: A possible therapeutic option

Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Domenico Pirritano, Aida Squillace, Giovambattista De Sarro, Luca Gallelli

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.

Original language	English
Pages (from-to)	815-818
Number of pages	4
Journal	Current Neuropharmacology
Volume	13
Issue number	6
Publication status	Published - 2015

Keywords

Cocaine dependence
Gamma-aminobutyric acid neurotransmission
Glutamatergic neurotransmission
Topiramate

ASJC Scopus subject areas

Clinical Neurology
Pharmacology (medical)
Pharmacology
Neurology
Psychiatry and Mental health

Cite this

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abstract = "Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.",

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author = "Antonio Siniscalchi and Antonello Bonci and Mercuri, {Nicola Biagio} and Domenico Pirritano and Aida Squillace and {De Sarro}, Giovambattista and Luca Gallelli",

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AU - Siniscalchi, Antonio

AU - Bonci, Antonello

AU - Mercuri, Nicola Biagio

AU - Pirritano, Domenico

AU - Squillace, Aida

AU - De Sarro, Giovambattista

AU - Gallelli, Luca

PY - 2015

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KW - Glutamatergic neurotransmission

KW - Topiramate

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The role of topiramate in the management of cocaine addiction: A possible therapeutic option

Abstract

Keywords

ASJC Scopus subject areas

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