The role of topiramate in the management of cocaine addiction: A possible therapeutic option

Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Domenico Pirritano, Aida Squillace, Giovambattista De Sarro, Luca Gallelli

Research output: Contribution to journalArticlepeer-review

Abstract

Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.

Original languageEnglish
Pages (from-to)815-818
Number of pages4
JournalCurrent Neuropharmacology
Volume13
Issue number6
Publication statusPublished - 2015

Keywords

  • Cocaine dependence
  • Gamma-aminobutyric acid neurotransmission
  • Glutamatergic neurotransmission
  • Topiramate

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health

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