Abstract
Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.
| Original language | English |
|---|---|
| Pages (from-to) | 815-818 |
| Number of pages | 4 |
| Journal | Current Neuropharmacology |
| Volume | 13 |
| Issue number | 6 |
| Publication status | Published - 2015 |
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Keywords
- Cocaine dependence
- Gamma-aminobutyric acid neurotransmission
- Glutamatergic neurotransmission
- Topiramate
ASJC Scopus subject areas
- Clinical Neurology
- Pharmacology (medical)
- Pharmacology
- Neurology
- Psychiatry and Mental health
Cite this
The role of topiramate in the management of cocaine addiction : A possible therapeutic option. / Siniscalchi, Antonio; Bonci, Antonello; Mercuri, Nicola Biagio; Pirritano, Domenico; Squillace, Aida; De Sarro, Giovambattista; Gallelli, Luca.
In: Current Neuropharmacology, Vol. 13, No. 6, 2015, p. 815-818.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of topiramate in the management of cocaine addiction
T2 - A possible therapeutic option
AU - Siniscalchi, Antonio
AU - Bonci, Antonello
AU - Mercuri, Nicola Biagio
AU - Pirritano, Domenico
AU - Squillace, Aida
AU - De Sarro, Giovambattista
AU - Gallelli, Luca
PY - 2015
Y1 - 2015
N2 - Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.
AB - Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.
KW - Cocaine dependence
KW - Gamma-aminobutyric acid neurotransmission
KW - Glutamatergic neurotransmission
KW - Topiramate
UR - http://www.scopus.com/inward/record.url?scp=84959313164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959313164&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84959313164
VL - 13
SP - 815
EP - 818
JO - Current Neuropharmacology
JF - Current Neuropharmacology
SN - 1570-159X
IS - 6
ER -