The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

Paolo Biancheri; Paolo Giuffrida; Guillermo H. Docena; Thomas T. MacDonald; Gino Roberto Corazza; Antonio Di Sabatino

doi:10.1016/j.cytogfr.2013.11.001

The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

Paolo Biancheri, Paolo Giuffrida, Guillermo H. Docena, Thomas T. MacDonald, Gino Roberto Corazza, Antonio Di Sabatino

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Transforming growth factor (TGF)-β, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-β also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-β signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-β signaling in chronic intestinal diseases.

Original language	English
Pages (from-to)	45-55
Number of pages	11
Journal	Cytokine and Growth Factor Reviews
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.cytogfr.2013.11.001
Publication status	Published - 2014

Keywords

Celiac disease
Crohn's disease
Myofibroblast
Regulatory T cell
Smad

ASJC Scopus subject areas

Immunology
Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Biochemistry, Genetics and Molecular Biology(all)

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The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut. / Biancheri, Paolo; Giuffrida, Paolo; Docena, Guillermo H.; MacDonald, Thomas T.; Corazza, Gino Roberto ; Di Sabatino, Antonio.

In: Cytokine and Growth Factor Reviews, Vol. 25, No. 1, 2014, p. 45-55.

Research output: Contribution to journal › Article › peer-review

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