The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

Paolo Biancheri, Paolo Giuffrida, Guillermo H. Docena, Thomas T. MacDonald, Gino Roberto Corazza, Antonio Di Sabatino

Research output: Contribution to journalArticlepeer-review

Abstract

Transforming growth factor (TGF)-β, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-β also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-β signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-β signaling in chronic intestinal diseases.

Original languageEnglish
Pages (from-to)45-55
Number of pages11
JournalCytokine and Growth Factor Reviews
Volume25
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Celiac disease
  • Crohn's disease
  • Myofibroblast
  • Regulatory T cell
  • Smad

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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