Ii ruolo dell'ecografia della loggia prostatica nella diagnosi delle recidive locali dopo prostatectomia radicale in caso di rialzo del PSA

Translated title of the contribution: The role of transrectal ultrasound of the prostatic fossa in the diagnosis of local recurrence after radical prostatectomy in case of PSA failure

Marco Roscigno, Vincenzo Scattoni, Marco Raber, Paolo Consonni, Francesco Montorsi, Alessandra Pasta, Roberto Bertini, Renzo Colombo, Luigi Da Pozzo, Massimo Freschi, Patrizio Rigatti

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study is to verify the diagnostic accuracy of transrectal ultrasound (TRUS) of vesico-urethral anastomosis in patients with PSA elevation (≥0,2 ng/mL) after radical prostatectomy, who received 4-6 random anastomotic biopsies of the prostatic fossa plus additional biopsies directed to TRUS detectable lesions. Material and Methods: Since 1992 up to now, 102 patients (mean age: 68.3±5.4 years) with PSA elevation after radical prostatectomy underwent TRUS of the vesico-urethral anastomosis and 4-6 TRUS-guided random biopsies plus 1-2 additional biopsies directed to TRUS detectable lesions. Pathologic stage was B (ASS classification) in 60% of cases, C in 36% and D in 4% (patients without hormonal treatment who underwent TRUS-guided biopsy because of TRUS detectable or palpable lesion). Results: The mean PSA at biopsy time was 2.1 ± 4.6 (SD) ng/mL (range: 0.2-31.6 ng/mL) with median PSA of 0.9 ng/mL. DRE was positive in 37% of cases, while TRUS was positive in 73%. Recurrent adenocarcinoma was detected in 51% of all patients and in 45% (26/57) of patients with PSA <1.0 ng/mL. TRUS sensitivity was higher (80%) than DRE (50%), but specificity was lower (37% vs 81%). The positive predictive value of TRUS detectable lesion was 60%. TRUS sensitivity and specificity increase with PSA elevation and sonographic aspects of prostatic fossa are statistically correlated with histology when PSA <1.2 ng/mL. Conclusions: TRUS of the vesico-urethral anastomosis seems to be more sensitive but less specific than DRE for prostatic cancer local recurrence. More than half of TRUS detectable lesions is positive at biopsy. TRUS and TRUS-guided biopsy accuracy are directly correlated with PSA elevation.

Translated title of the contributionThe role of transrectal ultrasound of the prostatic fossa in the diagnosis of local recurrence after radical prostatectomy in case of PSA failure
Original languageItalian
Pages (from-to)304-308
Number of pages5
JournalArchivio Italiano di Urologia e Andrologia
Volume74
Issue number4
Publication statusPublished - Dec 2002

ASJC Scopus subject areas

  • Nephrology
  • Urology

Fingerprint Dive into the research topics of 'The role of transrectal ultrasound of the prostatic fossa in the diagnosis of local recurrence after radical prostatectomy in case of PSA failure'. Together they form a unique fingerprint.

  • Cite this