The role of transsphenoidal surgery in the treatment of craniopharyngiomas

Giulio Maira, Carmelo Anile, Alessio Albanese, Daniel Cabezas, Flaminia Pardi, Andrea Vignati

Research output: Contribution to journalArticle


Object. The optimal approach for the surgical treatment of craniopharyngiomas is still debated. In all cases involving the sella turcica, the authors have exclusively used transsphenoidal surgery (TSS), assuming that this approach is less traumatic than an intracranial one. Moreover, TSS was also performed in some cases of purely suprasellar craniopharyngiomas. In this study the surgical indications and the results obtained in all patients who had undergone TSS were analyzed. Methods. In a series of 92 patients who underwent surgery for craniopharyngiomas, TSS was the first choice of approach in 57 cases (62%) consisting of 29 female and 28 male patients with ages ranging from 12 to 79 years (mean 35 years). The follow-up duration ranged from 2 to 20 years. A standard transsphenoidal approach was used in patients with an exclusively intrasellar (11 patients) or an intrasellar and suprasellar tumor (37 patients); in nine cases of tumors located exclusively above the sella turcica, a transsphenoidal presellar approach (seven patients) or a transsellar-transdiaphragmatic approach (two patients) was used. Total removal was performed in 36 patients (63%). All patients had good clinical results. Postoperative cerebrospinal fluid leakage occurred in 10 cases, but only one case required a surgical repair of the sella. Two patients died of late complications (3.5%). There were eight cases (14%) of tumor regrowth. Conclusions. The authors assert that, when used in appropriately located craniopharyngiomas and by neurosurgeons with extensive experience in pituitary surgery, TSS offers excellent results with minor risks.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalJournal of Neurosurgery
Issue number3
Publication statusPublished - Mar 2004


  • Craniopharyngioma
  • Sella turcica
  • Suprasellar tumor
  • Transsphenoidal approach

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'The role of transsphenoidal surgery in the treatment of craniopharyngiomas'. Together they form a unique fingerprint.

  • Cite this

    Maira, G., Anile, C., Albanese, A., Cabezas, D., Pardi, F., & Vignati, A. (2004). The role of transsphenoidal surgery in the treatment of craniopharyngiomas. Journal of Neurosurgery, 100(3), 445-451.