The Role of Tumour Necrosis Factor in the Pathogenesis of Immune-Mediated Diseases

C. Blandizzi, P. Gionchetti, A. Armuzzi, R. Caporali, S. Chimenti, R. Cimaz, L. Cimino, G. Lapadula, P. Lionetti, A. Marchesoni, A. Marcellusi, F. S. Mennini, C. Salvarani, G. Girolomoni

Research output: Contribution to journalArticle

Abstract

Immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis, psoriatic arthritis, psoriasis, axial spondyloarthropathies, Crohn's disease, ulcerative colitis and juvenile idiopathic arthritis, comprise a group of chronic disorders characterized by an immune-mediated pathogenesis. Although at clinical presentation these diseases appear unrelated, they have been recognized to share similar pathogenic mechanisms. Data from epidemiological and genetic studies further support the concept that IMIDs are interrelated, as they can co-occur in the same patient and share a similar genetic susceptibility. The specific aetiologies of IMIDs remain unknown, but all are known to involve dysregulation of the immune system, including an over-expression of the pro-inflammatory cytokine tumour necrosis factor (TNF). The pivotal role played by TNF in the pathogenesis and pathophysiology of IMIDs has been documented by extensive preclinical and clinical investigations, and confirmed by the efficacy of anti-TNF biotechnological drugs, such as etanercept, infliximab and adalimumab, in the therapeutic management of these disorders. In this narrative review, we discuss the available data on the TNF-dependent pathogenesis of IMIDs and associations among the different disorders. Although much remains to be discovered about the pathogenesis and aetiology of IMIDs, their common inflammatory pathological features may explain why they can be successfully targeted by anti-TNF drugs. Among these, adalimumab, a fully human monoclonal antibody, has been approved for treatment ofnine distinct IMID indications and it is likely to become a valuable therapeutic tool for this complex cluster of chronic inflammatory disorders.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalInternational Journal of Immunopathology and Pharmacology
Volume27
DOIs
Publication statusPublished - Jan 1 2014

    Fingerprint

Keywords

  • immune-mediated inflammatory disease
  • pathogenesis
  • Tumour necrosis factor (TNF)

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Cite this

Blandizzi, C., Gionchetti, P., Armuzzi, A., Caporali, R., Chimenti, S., Cimaz, R., Cimino, L., Lapadula, G., Lionetti, P., Marchesoni, A., Marcellusi, A., Mennini, F. S., Salvarani, C., & Girolomoni, G. (2014). The Role of Tumour Necrosis Factor in the Pathogenesis of Immune-Mediated Diseases. International Journal of Immunopathology and Pharmacology, 27, 1-10. https://doi.org/10.1177/03946320140270S101