The roles of brain noradrenaline and dopamine in the anorectic activity of diethylpropion in rats: A comparison with d-amphetamine

F. Borsini, C. Bendotti, M. Carli, E. Poggesi, R. Samanin

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Abstract

The anorectic activity of diethylpropion and d-amphetamine was studied in rats subjected to various treatments known to affect brain monoamines. The effect of diethylpropion, like that of d-amphetamine, was completely prevented by a lesion of the ventral noradrenergic bundle, which selectively decreases brain noradrenaline, but was not significantly modified in desipramine pretreated rats by an intraventricular injection of 6-hydroxydopamine, a condition decreasing only dopamine. Pretreatment with penfluridol significantly reduced the effect of d-amphetamine but not that of diethylpropion. A non-significant reduction of drug effect was found with alpha-methyl-p-tyrosine. Lesion of the nucleus medianus raphe, which destroys central serotonin neurons, or treatment with methergoline, a central serotonin antagonist, caused no changes in the effects of both compounds. The findings show that integrity of central noradrenergic neurons is an important condition for diethylpropion and d-amphetamine to exert their anorectic effect. Dopamine does not seem to play any role in the effect of diethylpropion but might contribute to that of d-amphetamine. The data are against any involvement of brain serotonin in diethylpropion anorexia.

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume26
Issue number1
Publication statusPublished - 1979

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Diethylpropion
Appetite Depressants
Dextroamphetamine
Rats
Dopamine
Brain
Norepinephrine
Neurons
Penfluridol
Serotonin
Metergoline
Intraventricular Injections
alpha-Methyltyrosine
Adrenergic Neurons
Serotonin Antagonists
Desipramine
Raphe Nuclei
Oxidopamine
Anorexia
Therapeutics

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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The roles of brain noradrenaline and dopamine in the anorectic activity of diethylpropion in rats : A comparison with d-amphetamine. / Borsini, F.; Bendotti, C.; Carli, M.; Poggesi, E.; Samanin, R.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 26, No. 1, 1979, p. 3-11.

Research output: Contribution to journalArticle

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