The Route of the Malignant Plasma Cell in Its Survival Niche: Exploring “Multiple Myelomas”

Antonio Giovanni Solimando, Matteo Claudio Da Vià, Niccolò Bolli, Torsten Steinbrunn

Research output: Contribution to journalArticlepeer-review

Abstract

Growing evidence points to multiple myeloma (MM) and its stromal microenvironment using several mechanisms to subvert effective immune and anti-tumor responses. Recent advances have uncovered the tumor-stromal cell influence in regulating the immune-microenvironment and have envisioned targeting these suppressive pathways to improve therapeutic outcomes. Neverthe-less, some subgroups of patients include those with particularly unfavorable prognoses. Biological stratification can be used to categorize patient-, disease-or therapy-related factors, or alternatively, these biological determinants can be included in a dynamic model that customizes a given treatment to a specific patient. Genetic heterogeneity and current knowledge enforce a systematic and comprehensive bench-to-bedside approach. Given the increasing role of cancer stem cells (CSCs) in better characterizing the pathogenesis of solid and hematological malignancies, disease relapse, and drug resistance, identifying and describing CSCs is of paramount importance in the management of MM. Even though the function of CSCs is well-known in other cancer types, their role in MM remains elusive. With this review, we aim to provide an update on MM homing and resilience in the bone marrow micro milieu. These data are particularly interesting for clinicians facing unmet medical needs while designing novel treatment approaches for MM.

Original languageEnglish
Article number3271
JournalCancers
Volume14
Issue number13
DOIs
Publication statusPublished - Jul 1 2022

Keywords

  • adhesion molecule
  • bone marrow homing
  • bone marrow immune-microenvironment
  • cancer stem cells
  • cell of origin
  • multiple myeloma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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