Abstract
Original language | English |
---|---|
Pages (from-to) | 1415-1422 |
Number of pages | 8 |
Journal | Eur. J. Surg. Oncol. |
Volume | 46 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Radiation therapy
- Sacral chordoma
- Surgery
- Surgical margins
- cancer radiotherapy
- cancer recurrence
- cancer surgery
- chordoma
- clinical target volume
- human
- outcome assessment
- particle therapy
- primary tumor
- priority journal
- prospective study
- radiation dose
- Review
- sacrum
- surgical approach
- surgical margin
- adverse event
- proton therapy
- radiotherapy dosage
- Chordoma
- Humans
- Margins of Excision
- Proton Therapy
- Radiotherapy Dosage
- Sacrum
Fingerprint Dive into the research topics of 'The sacral chordoma margin: European Journal of Surgical Oncology'. Together they form a unique fingerprint.
Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
The sacral chordoma margin : European Journal of Surgical Oncology. / Radaelli, S.; Fossati, P.; Stacchiotti, S.; Akiyama, T.; Asencio, J.M.; Bandiera, S.; Boglione, A.; Boland, P.; Bolle, S.; Bruland, Ø.; Brunello, A.; Bruzzi, P.; Campanacci, D.; Cananzi, F.; Capanna, R.; Casadei, R.; Cordoba, A.; Court, C.; Dei Tos, A.P.; DeLaney, T.F.; De Paoli, A.; De Pas, T.M.; Desai, A.; Di Brina, L.; Donati, D.M.; Fabbri, N.; Fiore, M.R.; Frezza, A.; Gambarotti, M.; Gasbarrini, A.; Georg, P.; Grignani, G.; Hindi, N.; Hug, E.B.; Jones, R.; Kawai, A.; Krol, A.D.; Le Grange, F.; Luzzati, A.; Marquina, G.; Martin-Benlloch, J.A.; Mazzocco, K.; Navarria, F.; Navarria, P.; Parchi, P.D.; Patel, S.; Pennacchioli, E.; Petrongari, M.G.; Picci, P.; Pollock, R.; Porcu, L.; Quagliuolo, V.; Sangalli, C.; Scheipl, S.; Scotto, G.M.; Spalek, M.; Steinmeier, T.; Timmermann, B.; Trama, A.; Uhl, M.; Valverde, C.; Varga, P.P.; Verges, R.; Weber, D.C.; Zoccali, C.; Casali, P.G.; Sommer, J.; Gronchi, A.
In: Eur. J. Surg. Oncol., Vol. 46, No. 8, 2020, p. 1415-1422.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The sacral chordoma margin
T2 - European Journal of Surgical Oncology
AU - Radaelli, S.
AU - Fossati, P.
AU - Stacchiotti, S.
AU - Akiyama, T.
AU - Asencio, J.M.
AU - Bandiera, S.
AU - Boglione, A.
AU - Boland, P.
AU - Bolle, S.
AU - Bruland, Ø.
AU - Brunello, A.
AU - Bruzzi, P.
AU - Campanacci, D.
AU - Cananzi, F.
AU - Capanna, R.
AU - Casadei, R.
AU - Cordoba, A.
AU - Court, C.
AU - Dei Tos, A.P.
AU - DeLaney, T.F.
AU - De Paoli, A.
AU - De Pas, T.M.
AU - Desai, A.
AU - Di Brina, L.
AU - Donati, D.M.
AU - Fabbri, N.
AU - Fiore, M.R.
AU - Frezza, A.
AU - Gambarotti, M.
AU - Gasbarrini, A.
AU - Georg, P.
AU - Grignani, G.
AU - Hindi, N.
AU - Hug, E.B.
AU - Jones, R.
AU - Kawai, A.
AU - Krol, A.D.
AU - Le Grange, F.
AU - Luzzati, A.
AU - Marquina, G.
AU - Martin-Benlloch, J.A.
AU - Mazzocco, K.
AU - Navarria, F.
AU - Navarria, P.
AU - Parchi, P.D.
AU - Patel, S.
AU - Pennacchioli, E.
AU - Petrongari, M.G.
AU - Picci, P.
AU - Pollock, R.
AU - Porcu, L.
AU - Quagliuolo, V.
AU - Sangalli, C.
AU - Scheipl, S.
AU - Scotto, G.M.
AU - Spalek, M.
AU - Steinmeier, T.
AU - Timmermann, B.
AU - Trama, A.
AU - Uhl, M.
AU - Valverde, C.
AU - Varga, P.P.
AU - Verges, R.
AU - Weber, D.C.
AU - Zoccali, C.
AU - Casali, P.G.
AU - Sommer, J.
AU - Gronchi, A.
N1 - Export Date: 5 March 2021 CODEN: EJSOE Correspondence Address: Radaelli, S.; Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori Via Giacomo Venezian 1, Italy; email: stefano.radaelli@istitutotumori.mi.it Funding text 1: None. References: Smoll, N.R., Gautschi, O.P., Radovanovic, I., Schaller K, K., Weber, D.C., Incidence and relative survival of chordomas: the standardized mortality ratio and the impact of chordomas on a population (2013) Cancer, 119 (11), pp. 2029-2037; Gatta, G., Capocaccia, R., Botta, L., Mallone, S., De Angelis, R., Ardanaz, E., Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet-a population-based study (2017) Lancet Oncol, 18 (8), pp. 1022-1039; Lau, C.S., Mahendraraj, K., Ward, A., Chamberlain, R.S., Pediatric chordomas: a population-based clinical outcome study involving 86 patients from the surveillance, epidemiology, and end result (seer) database (1973-2011) (2016) Pediatr Neurosurg, 51 (3), pp. 127-136; Stacchiotti, S., Gronchi, A., Fossati, P., Akiyama, T., Alapetite, C., Baumann, M., Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group (2017) Ann Oncol : Off J Eur Soc Med Oncol, 28 (6), pp. 1230-1242; Stacchiotti, S., Sommer, J., Building a global consensus approach to chordoma: a position paper from the medical and patient community (2015) Lancet Oncol, 16 (2), pp. e71-e83; Bergh, P., Kindblom, L.G., Gunterberg, B., Remotti, F., Ryd, W., Meis-Kindblom, J.M., Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients (2000) Cancer, 88 (9), pp. 2122-2134; Fuchs, B., Dickey, I.D., Yaszemski, M.J., Inwards, C.Y., Sim, F.H., Operative management of sacral chordoma. (2005) The Journal of bone and joint surgery (American Volume), 87 (10), pp. 2211-2216; Kayani, B., Sewell, M.D., Tan, K.A., Hanna, S.A., Williams, R., Pollock, R., Prognostic factors in the operative management of sacral chordomas (2015) World neurosurgery, 84 (5), pp. 1354-1361; Angelini, A., Pala, E., Calabro, T., Maraldi, M., Ruggieri, P., Prognostic factors in surgical resection of sacral chordoma (2015) J Surg Oncol, 112 (4), pp. 344-351; Ji, T., Guo, W., Yang, R., Tang, X., Wang, Y., Huang, L., What are the conditional survival and functional outcomes after surgical treatment of 115 patients with sacral chordoma? (2017) Clin Orthop Relat Res, 475 (3), pp. 620-630; Radaelli, S., Stacchiotti, S., Ruggieri, P., Donati, D., Casali, P.G., Palmerini, E., Sacral chordoma: long-term outcome of a large series of patients surgically treated at two reference centers (2016) Spine, 41 (12), pp. 1049-1057; Yang, Y., Niu, X., Li, Y., Liu, W., Xu, H., Recurrence and survival factors analysis of 171 cases of sacral chordoma in a single institute (2017) Eur Spine J: Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sec Cerv Spine Res Soc, 26 (7), pp. 1910-1916; Colangeli, S., Muratori, F., Bettini, L., Frenos, F., Totti, F., D'Arienzo, A., Surgical treatment of sacral chordoma: en bloc resection with negative margins is a determinant of the long-term outcome (2018) Surg Technol Int, 33; Varga, P.P., Szoverfi, Z., Fisher, C.G., Boriani, S., Gokaslan, Z.L., Dekutoski, M.B., Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival (2015) Eur Spine J: Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sec Cerv Spine Res Soc, 24 (5), pp. 1092-1101; Zoccali, C., Skoch, J., Patel, A., Walter, C.M., Maykowsky, P., Baaj, A.A., The surgical neurovascular anatomy relating to partial and complete sacral and sacroiliac resections: a cadaveric, anatomic study (2015) Eur Spine J: Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sec Cerv Spine Res Soc, 24 (5), pp. 1109-1113; Zoccali, C., Skoch, J., Patel, A.S., Walter, C.M., Maykowsky, P., Baaj, A.A., Residual neurological function after sacral root resection during en-bloc sacrectomy: a systematic review (2016) Eur Spine J: Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sec Cerv Spine Res Soc, 25 (12), pp. 3925-3931; Akiyama, T., Ogura, K., Gokita, T., Tsukushi, S., Iwata, S., Nakamura, T., Analysis of the infiltrative features of chordoma: the relationship between micro-skip metastasis and postoperative outcomes (2018) Ann Surg Oncol, 25 (4), pp. 912-919; Asavamongkolkul, A., Waikakul, S., Wide resection of sacral chordoma via a posterior approach (2012) Int Orthop, 36 (3), pp. 607-612; Kiatisevi, P., Piyaskulkaew, C., Kunakornsawat, S., Sukunthanak, B., What are the functional outcomes after total sacrectomy without spinopelvic reconstruction? (2017) Clin Orthop Relat Res, 475 (3), pp. 643-655; Ruggieri, P., Angelini, A., Ussia, G., Montalti, M., Mercuri, M., Surgical margins and local control in resection of sacral chordomas (2010) Clin Orthop Relat Res, 468 (11), pp. 2939-2947; Macki, M., De la Garza-Ramos, R., Murgatroyd, A.A., Mullinix, K.P., Sun, X., Cunningham, B.W., Comprehensive biomechanical analysis of three reconstruction techniques following total sacrectomy: an in vitro human cadaveric model (2017) J Neurosurg Spine, 27 (5), pp. 570-577; Guo, W., Tang, X., Zang, J., Ji, T., One-stage total en bloc sacrectomy: a novel technique and report of 9 cases (2013) Spine, 38 (10), pp. E626-E631; Kim, J.E., Pang, J., Christensen, J.M., Coon, D., Zadnik, P.L., Wolinsky, J.P., Soft-tissue reconstruction after total en bloc sacrectomy (2015) J Neurosurg Spine, 22 (6), pp. 571-581; Reynolds, J.J., Khundkar, R., Boriani, S., Williams, R., Rhines, L.D., Kawahara, N., Soft tissue and bone defect management in total sacrectomy for primary sacral tumors: a systematic review with expert recommendations (2016) Spine, 41, pp. S199-S204; Kiiski, J., Kuokkanen, H.O., Kaariainen, M., Kaartinen, I.S., Pakarinen, T.K., Laitinen, M.K., Clinical results and quality of life after reconstruction following sacrectomy for primary bone malignancy (2018) J Plast Reconstr Aesthetic Surg : JPRAS, 71 (12), pp. 1730-1739; Ailon, T., Torabi, R., Fisher, C.G., Rhines, L.D., Clarke, M.J., Bettegowda, C., Management of locally recurrent chordoma of the mobile spine and sacrum: a systematic review (2016) Spine, 41, pp. S193-S198; Imai, R., Kamada, T., Araki, N., Carbon ion radiation therapy for unresectable sacral chordoma: an analysis of 188 cases (2016) Int J Radiat Oncol Biol Phys, 95 (1), pp. 322-327; Nishida, Y., Kamada, T., Imai, R., Tsukushi, S., Yamada, Y., Sugiura, H., Clinical outcome of sacral chordoma with carbon ion radiotherapy compared with surgery (2011) Int J Radiat Oncol Biol Phys, 79 (1), pp. 110-116; McDonald, M.W., Linton, O.R., Shah, M.V., Proton therapy for reirradiation of progressive or recurrent chordoma (2013) Int J Radiat Oncol Biol Phys, 87 (5), pp. 1107-1114; Youn, S.H., Cho, K.H., Kim, J.Y., Ha, B., Lim, Y.K., Jeong, J.H., Clinical outcome of proton therapy for patients with chordomas (2018) Radiation oncology journal, 36 (3), pp. 182-191; Breteau, N., Demasure, M., Lescrainier, J., Sabbattier, R., Michenet, P., Sacrococcygeal chordomas: potential role of high LET therapy (1998) Recent Results Canc Res. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 150, pp. 148-155; Mima, M., Demizu, Y., Jin, D., Hashimoto, N., Takagi, M., Terashima, K., Particle therapy using carbon ions or protons as a definitive therapy for patients with primary sacral chordoma (2014) Br J Radiol, 87 (1033), p. 20130512; Uhl, M., Welzel, T., Jensen, A., Ellerbrock, M., Haberer, T., Jäkel, O., Carbon ion beam treatment in patients with primary and recurrent sacrococcygeal chordoma (2015) Strahlenther Onkol : Organ der Deutschen Rontgengesellschaft, 191 (7), pp. 597-603. , [et al]; Kabolizadeh, P., Chen, Y.L., Liebsch, N., Hornicek, F.J., Schwab, J.H., Choy, E., Updated outcome and analysis of tumor response in mobile spine and sacral chordoma treated with definitive high-dose photon/proton radiation therapy (2017) Int J Radiat Oncol Biol Phys, 97 (2), pp. 254-262; Aibe, N., Demizu, Y., Sulaiman, N.S., Matsuo, Y., Mima, M., Nagano, F., Outcomes of patients with primary sacral chordoma treated with definitive proton beam therapy (2018) Int J Radiat Oncol Biol Phys, 100 (4), pp. 972-979; Rotondo, R.L., Folkert, W., Liebsch, N.J., Chen, Y.L., Pedlow, F.X., Schwab, J.H., High-dose proton-based radiation therapy in the management of spine chordomas: outcomes and clinicopathological prognostic factors (2015) J Neurosurg Spine, 23 (6), pp. 788-797; DeLaney, T.F., Liebsch, N.J., Pedlow, F.X., Adams, J., Dean, S., Yeap, B.Y., Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas (2009) Int J Radiat Oncol Biol Phys, 74 (3), pp. 732-739; DeLaney, T.F., Liebsch, N.J., Pedlow, F.X., Adams, J., Weyman, E.A., Yeap, B.Y., Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas (2014) J Surg Oncol, 110 (2), pp. 115-122; Park, L., Delaney, T.F., Liebsch, N.J., Hornicek, F.J., Goldberg, S., Mankin, H., Sacral chordomas: impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor (2006) Int J Radiat Oncol Biol Phys, 65 (5), pp. 1514-1521; Staab, A., Rutz, H.P., Ares, C., Timmermann, B., Schneider, R., Bolsi, A., Spot-scanning-based proton therapy for extracranial chordoma (2011) Int J Radiat Oncol Biol Phys, 81 (4), pp. e489-e496; Fossati, P., Molinelli, S., Matsufuji, N., Ciocca, M., Mirandola, A., Mairani, A., Dose prescription in carbon ion radiotherapy: a planning study to compare NIRS and LEM approaches with a clinically-oriented strategy (2012) Phys Med Biol, 57 (22), pp. 7543-7554; Molinelli, S., Magro, G., Mairani, A., Matsufuji, N., Kanematsu, N., Inaniwa, T., Dose prescription in carbon ion radiotherapy: how to compare two different RBE-weighted dose calculation systems (2016) Radiother Oncol : J Eur Soc Therapeut Radiol Oncol, 120 (2), pp. 307-312; Steinstrater, O., Grun, R., Scholz, U., Friedrich, T., Durante, M., Scholz, M., Mapping of RBE-weighted doses between HIMAC- and LEM-Based treatment planning systems for carbon ion therapy (2012) Int J Radiat Oncol Biol Phys, 84 (3), pp. 854-860; Chen, Y.L., Liebsch, N., Kobayashi, W., Goldberg, S., Kirsch, D., Calkins, G., Definitive high-dose photon/proton radiotherapy for unresected mobile spine and sacral chordomas (2013) Spine, 38 (15), pp. E930-E936; Bostel, T., Nicolay, N.H., Welzel, T., Bruckner, T., Mattke, M., Akbaba, S., Sacral insufficiency fractures after high-dose carbon-ion based radiotherapy of sacral chordomas (2018) Radiat Oncol, 13 (1), p. 154; Osler, P., Bredella, M.A., Hess, K.A., Janssen, S.J., Park, C.J., Chen, Y.L., Sacral insufficiency fractures are common after high-dose radiation for sacral chordomas treated with or without surgery (2016) Clin Orthop Relat Res, 474 (3), pp. 766-772; Lebellec, L., Chauffert, B., Blay, J.Y., Le Cesne, A., Chevreau, C., Bompas, E., Advanced chordoma treated by first-line molecular targeted therapies: outcomes and prognostic factors. A retrospective study of the French Sarcoma Group (GSF/GETO) and the Association des Neuro-Oncologues d'Expression Francaise (ANOCEF) (2017) Eur J Canc, 79, pp. 119-128; Stacchiotti, S., Morosi, C., Lo Vullo, S., Casale, A., Palassini, E., Frezza, A.M., Imatinib and everolimus in patients with progressing advanced chordoma: a Phase 2 clinical study (2018) Cancer, 15124 (20), pp. 4056-4063
PY - 2020
Y1 - 2020
N2 - Objective: Aim of the manuscript is to discuss how to improve margins in sacral chordoma. Background: Chordoma is a rare neoplasm, arising in half cases from the sacrum, with reported local failure in >50% after surgery. Methods: A multidisciplinary meeting of the “Chordoma Global Consensus Group” was held in Milan in 2017, focusing on challenges in defining and achieving optimal margins in chordoma with respect to surgery, definitive particle radiation therapy (RT) and medical therapies. This review aims to report on the outcome of the consensus meeting and to provide a summary of the most recent evidence in this field. Possible new ways forward, including on-going international clinical studies, are discussed. Results: En-bloc tumor-sacrum resection is the cornerstone of treatment of primary sacral chordoma, aiming to achieve negative microscopic margins. Radical definitive particle therapy seems to offer a similar outcome compared to surgery, although confirmation in comparative trials is lacking; besides there is still a certain degree of technical variability across institutions, corresponding to different fields of treatment and different tumor coverage. To address some of these questions, a prospective, randomized international study comparing surgery versus definitive high-dose RT is ongoing. Available data do not support the routine use of any medical therapy as (neo)adjuvant/cytoreductive treatment. Conclusion: Given the significant influence of margins status on local control in patients with primary localized sacral chordoma, the clear definition of adequate margins and a standard local approach across institutions for both surgery and particle RT is vital for improving the management of these patients. © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology
AB - Objective: Aim of the manuscript is to discuss how to improve margins in sacral chordoma. Background: Chordoma is a rare neoplasm, arising in half cases from the sacrum, with reported local failure in >50% after surgery. Methods: A multidisciplinary meeting of the “Chordoma Global Consensus Group” was held in Milan in 2017, focusing on challenges in defining and achieving optimal margins in chordoma with respect to surgery, definitive particle radiation therapy (RT) and medical therapies. This review aims to report on the outcome of the consensus meeting and to provide a summary of the most recent evidence in this field. Possible new ways forward, including on-going international clinical studies, are discussed. Results: En-bloc tumor-sacrum resection is the cornerstone of treatment of primary sacral chordoma, aiming to achieve negative microscopic margins. Radical definitive particle therapy seems to offer a similar outcome compared to surgery, although confirmation in comparative trials is lacking; besides there is still a certain degree of technical variability across institutions, corresponding to different fields of treatment and different tumor coverage. To address some of these questions, a prospective, randomized international study comparing surgery versus definitive high-dose RT is ongoing. Available data do not support the routine use of any medical therapy as (neo)adjuvant/cytoreductive treatment. Conclusion: Given the significant influence of margins status on local control in patients with primary localized sacral chordoma, the clear definition of adequate margins and a standard local approach across institutions for both surgery and particle RT is vital for improving the management of these patients. © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology
KW - Radiation therapy
KW - Sacral chordoma
KW - Surgery
KW - Surgical margins
KW - cancer radiotherapy
KW - cancer recurrence
KW - cancer surgery
KW - chordoma
KW - clinical target volume
KW - human
KW - outcome assessment
KW - particle therapy
KW - primary tumor
KW - priority journal
KW - prospective study
KW - radiation dose
KW - Review
KW - sacrum
KW - surgical approach
KW - surgical margin
KW - adverse event
KW - proton therapy
KW - radiotherapy dosage
KW - Chordoma
KW - Humans
KW - Margins of Excision
KW - Proton Therapy
KW - Radiotherapy Dosage
KW - Sacrum
U2 - 10.1016/j.ejso.2020.04.028
DO - 10.1016/j.ejso.2020.04.028
M3 - Article
VL - 46
SP - 1415
EP - 1422
JO - Eur. J. Surg. Oncol.
JF - Eur. J. Surg. Oncol.
SN - 0748-7983
IS - 8
ER -