Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1415-1422 |
| Number of pages | 8 |
| Journal | Eur. J. Surg. Oncol. |
| Volume | 46 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2020 |
Keywords
- Radiation therapy
- Sacral chordoma
- Surgery
- Surgical margins
- cancer radiotherapy
- cancer recurrence
- cancer surgery
- chordoma
- clinical target volume
- human
- outcome assessment
- particle therapy
- primary tumor
- priority journal
- prospective study
- radiation dose
- Review
- sacrum
- surgical approach
- surgical margin
- adverse event
- proton therapy
- radiotherapy dosage
- Chordoma
- Humans
- Margins of Excision
- Proton Therapy
- Radiotherapy Dosage
- Sacrum
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The sacral chordoma margin : European Journal of Surgical Oncology. / Radaelli, S.; Fossati, P.; Stacchiotti, S.; Akiyama, T.; Asencio, J.M.; Bandiera, S.; Boglione, A.; Boland, P.; Bolle, S.; Bruland, Ø.; Brunello, A.; Bruzzi, P.; Campanacci, D.; Cananzi, F.; Capanna, R.; Casadei, R.; Cordoba, A.; Court, C.; Dei Tos, A.P.; DeLaney, T.F.; De Paoli, A.; De Pas, T.M.; Desai, A.; Di Brina, L.; Donati, D.M.; Fabbri, N.; Fiore, M.R.; Frezza, A.; Gambarotti, M.; Gasbarrini, A.; Georg, P.; Grignani, G.; Hindi, N.; Hug, E.B.; Jones, R.; Kawai, A.; Krol, A.D.; Le Grange, F.; Luzzati, A.; Marquina, G.; Martin-Benlloch, J.A.; Mazzocco, K.; Navarria, F.; Navarria, P.; Parchi, P.D.; Patel, S.; Pennacchioli, E.; Petrongari, M.G.; Picci, P.; Pollock, R.; Porcu, L.; Quagliuolo, V.; Sangalli, C.; Scheipl, S.; Scotto, G.M.; Spalek, M.; Steinmeier, T.; Timmermann, B.; Trama, A.; Uhl, M.; Valverde, C.; Varga, P.P.; Verges, R.; Weber, D.C.; Zoccali, C.; Casali, P.G.; Sommer, J.; Gronchi, A.
In: Eur. J. Surg. Oncol., Vol. 46, No. 8, 2020, p. 1415-1422.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The sacral chordoma margin
T2 - European Journal of Surgical Oncology
AU - Radaelli, S.
AU - Fossati, P.
AU - Stacchiotti, S.
AU - Akiyama, T.
AU - Asencio, J.M.
AU - Bandiera, S.
AU - Boglione, A.
AU - Boland, P.
AU - Bolle, S.
AU - Bruland, Ø.
AU - Brunello, A.
AU - Bruzzi, P.
AU - Campanacci, D.
AU - Cananzi, F.
AU - Capanna, R.
AU - Casadei, R.
AU - Cordoba, A.
AU - Court, C.
AU - Dei Tos, A.P.
AU - DeLaney, T.F.
AU - De Paoli, A.
AU - De Pas, T.M.
AU - Desai, A.
AU - Di Brina, L.
AU - Donati, D.M.
AU - Fabbri, N.
AU - Fiore, M.R.
AU - Frezza, A.
AU - Gambarotti, M.
AU - Gasbarrini, A.
AU - Georg, P.
AU - Grignani, G.
AU - Hindi, N.
AU - Hug, E.B.
AU - Jones, R.
AU - Kawai, A.
AU - Krol, A.D.
AU - Le Grange, F.
AU - Luzzati, A.
AU - Marquina, G.
AU - Martin-Benlloch, J.A.
AU - Mazzocco, K.
AU - Navarria, F.
AU - Navarria, P.
AU - Parchi, P.D.
AU - Patel, S.
AU - Pennacchioli, E.
AU - Petrongari, M.G.
AU - Picci, P.
AU - Pollock, R.
AU - Porcu, L.
AU - Quagliuolo, V.
AU - Sangalli, C.
AU - Scheipl, S.
AU - Scotto, G.M.
AU - Spalek, M.
AU - Steinmeier, T.
AU - Timmermann, B.
AU - Trama, A.
AU - Uhl, M.
AU - Valverde, C.
AU - Varga, P.P.
AU - Verges, R.
AU - Weber, D.C.
AU - Zoccali, C.
AU - Casali, P.G.
AU - Sommer, J.
AU - Gronchi, A.
N1 - Export Date: 5 March 2021 CODEN: EJSOE Correspondence Address: Radaelli, S.; Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori Via Giacomo Venezian 1, Italy; email: stefano.radaelli@istitutotumori.mi.it Funding text 1: None. 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(2017) Clin Orthop Relat Res, 475 (3), pp. 643-655; Ruggieri, P., Angelini, A., Ussia, G., Montalti, M., Mercuri, M., Surgical margins and local control in resection of sacral chordomas (2010) Clin Orthop Relat Res, 468 (11), pp. 2939-2947; Macki, M., De la Garza-Ramos, R., Murgatroyd, A.A., Mullinix, K.P., Sun, X., Cunningham, B.W., Comprehensive biomechanical analysis of three reconstruction techniques following total sacrectomy: an in vitro human cadaveric model (2017) J Neurosurg Spine, 27 (5), pp. 570-577; Guo, W., Tang, X., Zang, J., Ji, T., One-stage total en bloc sacrectomy: a novel technique and report of 9 cases (2013) Spine, 38 (10), pp. E626-E631; Kim, J.E., Pang, J., Christensen, J.M., Coon, D., Zadnik, P.L., Wolinsky, J.P., Soft-tissue reconstruction after total en bloc sacrectomy (2015) J Neurosurg Spine, 22 (6), pp. 571-581; Reynolds, J.J., Khundkar, R., Boriani, S., Williams, R., Rhines, L.D., Kawahara, N., Soft tissue and bone defect management in total sacrectomy for primary sacral tumors: a systematic review with expert recommendations (2016) Spine, 41, pp. S199-S204; Kiiski, J., Kuokkanen, H.O., Kaariainen, M., Kaartinen, I.S., Pakarinen, T.K., Laitinen, M.K., Clinical results and quality of life after reconstruction following sacrectomy for primary bone malignancy (2018) J Plast Reconstr Aesthetic Surg : JPRAS, 71 (12), pp. 1730-1739; Ailon, T., Torabi, R., Fisher, C.G., Rhines, L.D., Clarke, M.J., Bettegowda, C., Management of locally recurrent chordoma of the mobile spine and sacrum: a systematic review (2016) Spine, 41, pp. S193-S198; Imai, R., Kamada, T., Araki, N., Carbon ion radiation therapy for unresectable sacral chordoma: an analysis of 188 cases (2016) Int J Radiat Oncol Biol Phys, 95 (1), pp. 322-327; Nishida, Y., Kamada, T., Imai, R., Tsukushi, S., Yamada, Y., Sugiura, H., Clinical outcome of sacral chordoma with carbon ion radiotherapy compared with surgery (2011) Int J Radiat Oncol Biol Phys, 79 (1), pp. 110-116; McDonald, M.W., Linton, O.R., Shah, M.V., Proton therapy for reirradiation of progressive or recurrent chordoma (2013) Int J Radiat Oncol Biol Phys, 87 (5), pp. 1107-1114; Youn, S.H., Cho, K.H., Kim, J.Y., Ha, B., Lim, Y.K., Jeong, J.H., Clinical outcome of proton therapy for patients with chordomas (2018) Radiation oncology journal, 36 (3), pp. 182-191; Breteau, N., Demasure, M., Lescrainier, J., Sabbattier, R., Michenet, P., Sacrococcygeal chordomas: potential role of high LET therapy (1998) Recent Results Canc Res. 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PY - 2020
Y1 - 2020
N2 - Objective: Aim of the manuscript is to discuss how to improve margins in sacral chordoma. Background: Chordoma is a rare neoplasm, arising in half cases from the sacrum, with reported local failure in >50% after surgery. Methods: A multidisciplinary meeting of the “Chordoma Global Consensus Group” was held in Milan in 2017, focusing on challenges in defining and achieving optimal margins in chordoma with respect to surgery, definitive particle radiation therapy (RT) and medical therapies. This review aims to report on the outcome of the consensus meeting and to provide a summary of the most recent evidence in this field. Possible new ways forward, including on-going international clinical studies, are discussed. Results: En-bloc tumor-sacrum resection is the cornerstone of treatment of primary sacral chordoma, aiming to achieve negative microscopic margins. Radical definitive particle therapy seems to offer a similar outcome compared to surgery, although confirmation in comparative trials is lacking; besides there is still a certain degree of technical variability across institutions, corresponding to different fields of treatment and different tumor coverage. To address some of these questions, a prospective, randomized international study comparing surgery versus definitive high-dose RT is ongoing. Available data do not support the routine use of any medical therapy as (neo)adjuvant/cytoreductive treatment. Conclusion: Given the significant influence of margins status on local control in patients with primary localized sacral chordoma, the clear definition of adequate margins and a standard local approach across institutions for both surgery and particle RT is vital for improving the management of these patients. © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology
AB - Objective: Aim of the manuscript is to discuss how to improve margins in sacral chordoma. Background: Chordoma is a rare neoplasm, arising in half cases from the sacrum, with reported local failure in >50% after surgery. Methods: A multidisciplinary meeting of the “Chordoma Global Consensus Group” was held in Milan in 2017, focusing on challenges in defining and achieving optimal margins in chordoma with respect to surgery, definitive particle radiation therapy (RT) and medical therapies. This review aims to report on the outcome of the consensus meeting and to provide a summary of the most recent evidence in this field. Possible new ways forward, including on-going international clinical studies, are discussed. Results: En-bloc tumor-sacrum resection is the cornerstone of treatment of primary sacral chordoma, aiming to achieve negative microscopic margins. Radical definitive particle therapy seems to offer a similar outcome compared to surgery, although confirmation in comparative trials is lacking; besides there is still a certain degree of technical variability across institutions, corresponding to different fields of treatment and different tumor coverage. To address some of these questions, a prospective, randomized international study comparing surgery versus definitive high-dose RT is ongoing. Available data do not support the routine use of any medical therapy as (neo)adjuvant/cytoreductive treatment. Conclusion: Given the significant influence of margins status on local control in patients with primary localized sacral chordoma, the clear definition of adequate margins and a standard local approach across institutions for both surgery and particle RT is vital for improving the management of these patients. © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology
KW - Radiation therapy
KW - Sacral chordoma
KW - Surgery
KW - Surgical margins
KW - cancer radiotherapy
KW - cancer recurrence
KW - cancer surgery
KW - chordoma
KW - clinical target volume
KW - human
KW - outcome assessment
KW - particle therapy
KW - primary tumor
KW - priority journal
KW - prospective study
KW - radiation dose
KW - Review
KW - sacrum
KW - surgical approach
KW - surgical margin
KW - adverse event
KW - proton therapy
KW - radiotherapy dosage
KW - Chordoma
KW - Humans
KW - Margins of Excision
KW - Proton Therapy
KW - Radiotherapy Dosage
KW - Sacrum
U2 - 10.1016/j.ejso.2020.04.028
DO - 10.1016/j.ejso.2020.04.028
M3 - Article
VL - 46
SP - 1415
EP - 1422
JO - Eur. J. Surg. Oncol.
JF - Eur. J. Surg. Oncol.
SN - 0748-7983
IS - 8
ER -