The same human alloreactive T cell clone can help both B lymphocytes and specific cytotoxic precursors

D. Ramarli, B. Parodi, M. Fabbi, G. Corte, A. Lanzavecchia

Research output: Contribution to journalArticle

Abstract

Human alloreactive proliferating T cell clones have been compared for their capacity to provide help for B cell activation and the generation of a specific cytotoxic response. The results demonstrate that, when triggered by the relevant alloantigen, the same T cell clone can induce a strong polyclonal B cell activation and serve as the only source of helper cells for the generation of a specific cytotoxic response by any source of CTL precursors against any stimulator cell present in culture.

Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalJournal of Experimental Medicine
Volume159
Issue number1
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Immunology

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