The “Sarcopenia and Physical fRailty IN older people

multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods

Francesco Landi, Matteo Cesari, Riccardo Calvani, Antonio Cherubini, Mauro Di Bari, Raphael Bejuit, Jerome Mshid, Sandrine Andrieu, Alan J. Sinclair, Cornel C. Sieber, Bruno Vellas, Eva Topinkova, Timo Strandberg, Leocadio Rodriguez-Manas, Fabrizia Lattanzio, Marco Pahor, Ronenn Roubenoff, Alfonso J Cruz-Jentoft, Roberto Bernabei, Emanuele Marzetti & 1 others on behalf of the SPRINTT Consortium

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The sustainability of health and social care systems is threatened by a growing population of older persons with heterogeneous needs related to multimorbidity, frailty, and increased risk of functional impairment. Since disability is difficult to reverse in old age and is extremely burdensome for individuals and society, novel strategies should be devised to preserve adequate levels of function and independence in late life. The development of mobility disability, an early event in the disablement process, precedes and predicts more severe forms of inability. Its prevention is, therefore, critical to impede the transition to overt disability. For this reason, the Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT) project is conducting a randomized controlled trial (RCT) to test a multicomponent intervention (MCI) specifically designed to prevent mobility disability in high-risk older persons. SPRINTT is a phase III, multicenter RCT aimed at comparing the efficacy of a MCI, based on long-term structured physical activity, nutritional counseling/dietary intervention, and an information and communication technology intervention, versus a healthy aging lifestyle education program designed to prevent mobility disability in 1500 older persons with physical frailty and sarcopenia who will be followed for up to 36 months. The primary outcome of the SPRINTT trial is mobility disability, operationalized as the inability to walk for 400 m within 15 min, without sitting, help of another person, or the use of a walker. Secondary outcomes include changes in muscle mass and strength, persistent mobility disability, falls and injurious falls, disability in activities of daily living, nutritional status, cognition, mood, the use of healthcare resources, cost-effectiveness analysis, quality of life, and mortality rate. SPRINTT results are expected to promote significant advancements in the management of frail older persons at high risk of disability from both clinical and regulatory perspectives. The findings are also projected to pave the way for major investments in the field of disability prevention in old age.

Original languageEnglish
Pages (from-to)89-100
Number of pages12
JournalAging clinical and experimental research
Volume29
Issue number1
DOIs
Publication statusPublished - Feb 1 2017

Fingerprint

Sarcopenia
Randomized Controlled Trials
Muscle Strength
Activities of Daily Living
Nutritional Status
Health Care Costs
Cognition
Cost-Benefit Analysis
Comorbidity
Counseling
Communication
Quality of Life
Technology
Delivery of Health Care
Education
Mortality
Population

Keywords

  • Disability
  • Functional impairment
  • Nutrition
  • Physical activity
  • Prevention
  • Unmet needs

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

The “Sarcopenia and Physical fRailty IN older people : multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods. / Landi, Francesco; Cesari, Matteo; Calvani, Riccardo; Cherubini, Antonio; Bari, Mauro Di; Bejuit, Raphael; Mshid, Jerome; Andrieu, Sandrine; Sinclair, Alan J.; Sieber, Cornel C.; Vellas, Bruno; Topinkova, Eva; Strandberg, Timo; Rodriguez-Manas, Leocadio; Lattanzio, Fabrizia; Pahor, Marco; Roubenoff, Ronenn; Cruz-Jentoft, Alfonso J; Bernabei, Roberto; Marzetti, Emanuele; on behalf of the SPRINTT Consortium.

In: Aging clinical and experimental research, Vol. 29, No. 1, 01.02.2017, p. 89-100.

Research output: Contribution to journalArticle

Landi, F, Cesari, M, Calvani, R, Cherubini, A, Bari, MD, Bejuit, R, Mshid, J, Andrieu, S, Sinclair, AJ, Sieber, CC, Vellas, B, Topinkova, E, Strandberg, T, Rodriguez-Manas, L, Lattanzio, F, Pahor, M, Roubenoff, R, Cruz-Jentoft, AJ, Bernabei, R, Marzetti, E & on behalf of the SPRINTT Consortium 2017, 'The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods', Aging clinical and experimental research, vol. 29, no. 1, pp. 89-100. https://doi.org/10.1007/s40520-016-0715-2
Landi, Francesco ; Cesari, Matteo ; Calvani, Riccardo ; Cherubini, Antonio ; Bari, Mauro Di ; Bejuit, Raphael ; Mshid, Jerome ; Andrieu, Sandrine ; Sinclair, Alan J. ; Sieber, Cornel C. ; Vellas, Bruno ; Topinkova, Eva ; Strandberg, Timo ; Rodriguez-Manas, Leocadio ; Lattanzio, Fabrizia ; Pahor, Marco ; Roubenoff, Ronenn ; Cruz-Jentoft, Alfonso J ; Bernabei, Roberto ; Marzetti, Emanuele ; on behalf of the SPRINTT Consortium. / The “Sarcopenia and Physical fRailty IN older people : multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods. In: Aging clinical and experimental research. 2017 ; Vol. 29, No. 1. pp. 89-100.
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