The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants

For the SPRINTT consortium

Research output: Contribution to journalArticle

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Abstract

Background: The ongoing “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)” randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. Methods: The identification of PF&S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick “participant profiling” questionnaire was devised to facilitate PF&S case finding. Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. Conclusion: PF&S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.

Original languageEnglish
Pages (from-to)48-57
Number of pages10
JournalExperimental Gerontology
Volume113
DOIs
Publication statusPublished - Nov 1 2018

Fingerprint

Sarcopenia
Screening
Randomized Controlled Trials
Health
Comorbidity
Catchments
Muscle
Mass Media
Health Services Needs and Demand
National Institutes of Health (U.S.)
Ambulatory Care
Communication
Testing
Therapeutics
Demography
Interviews
Muscles
Population

Keywords

  • Functional impairment
  • Mobility disability
  • Physical performance
  • Prevention
  • Recruitment
  • Skeletal muscle

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Cite this

@article{cd64f1116f6845c686f3bcf6e5f85e9b,
title = "The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants",
abstract = "Background: The ongoing “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)” randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. Methods: The identification of PF&S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick “participant profiling” questionnaire was devised to facilitate PF&S case finding. Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. Conclusion: PF&S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.",
keywords = "Functional impairment, Mobility disability, Physical performance, Prevention, Recruitment, Skeletal muscle",
author = "{For the SPRINTT consortium} and Emanuele Marzetti and Matteo Cesari and Riccardo Calvani and J{\'e}r{\^o}me Msihid and Matteo Tosato and Leocadio Rodriguez-Ma{\~n}as and Fabrizia Lattanzio and Antonio Cherubini and Rapha{\"e}l Bejuit and {Di Bari}, Mauro and Marcello Maggio and Bruno Vellas and Thierry Dantoine and Cruz-Jentoft, {Alfonso J.} and Sieber, {Cornel C.} and Ellen Freiberger and Anna Skalska and Tomasz Grodzicki and Sinclair, {Alan J.} and Eva Topinkova and Ingrid R{\'y}znarov{\'a} and Timo Strandberg and Schols, {Annemie M.W.J.} and Schols, {Jos M.G.A.} and Regina Roller-Wirnsberger and J{\'o}nsson, {P{\'a}lmi V.} and Alfons Ramel and {Del Signore}, Susanna and Marco Pahor and Ronenn Roubenoff and Roberto Bernabei and Francesco Landi",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.exger.2018.09.017",
language = "English",
volume = "113",
pages = "48--57",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - The “Sarcopenia and Physical fRailty IN older people

T2 - multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants

AU - For the SPRINTT consortium

AU - Marzetti, Emanuele

AU - Cesari, Matteo

AU - Calvani, Riccardo

AU - Msihid, Jérôme

AU - Tosato, Matteo

AU - Rodriguez-Mañas, Leocadio

AU - Lattanzio, Fabrizia

AU - Cherubini, Antonio

AU - Bejuit, Raphaël

AU - Di Bari, Mauro

AU - Maggio, Marcello

AU - Vellas, Bruno

AU - Dantoine, Thierry

AU - Cruz-Jentoft, Alfonso J.

AU - Sieber, Cornel C.

AU - Freiberger, Ellen

AU - Skalska, Anna

AU - Grodzicki, Tomasz

AU - Sinclair, Alan J.

AU - Topinkova, Eva

AU - Rýznarová, Ingrid

AU - Strandberg, Timo

AU - Schols, Annemie M.W.J.

AU - Schols, Jos M.G.A.

AU - Roller-Wirnsberger, Regina

AU - Jónsson, Pálmi V.

AU - Ramel, Alfons

AU - Del Signore, Susanna

AU - Pahor, Marco

AU - Roubenoff, Ronenn

AU - Bernabei, Roberto

AU - Landi, Francesco

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: The ongoing “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)” randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. Methods: The identification of PF&S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick “participant profiling” questionnaire was devised to facilitate PF&S case finding. Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. Conclusion: PF&S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.

AB - Background: The ongoing “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)” randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. Methods: The identification of PF&S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick “participant profiling” questionnaire was devised to facilitate PF&S case finding. Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. Conclusion: PF&S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.

KW - Functional impairment

KW - Mobility disability

KW - Physical performance

KW - Prevention

KW - Recruitment

KW - Skeletal muscle

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U2 - 10.1016/j.exger.2018.09.017

DO - 10.1016/j.exger.2018.09.017

M3 - Article

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VL - 113

SP - 48

EP - 57

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

ER -