The scavenging capacity of serum influences haemoglobin glycosylation in NIDDM patients

R. Testa, A. R. Bonfigli, J. Testa, S. Manfrini, L. Piantanelli, M. Marra, C. Fieri

Research output: Contribution to journalArticle

Abstract

The present experiment was designed to determine whether scavenging capacity of serum, in addition to glucose level, influences haemoglobin glycosylation in non-insulin dependent diabetic patients. For this purpose forty-seven patients homogeneous for age, disease duration, therapy and glyco-metabolic control were selected. Fasting and post-prandial glycaemia and insulinemia as well as glycosuria were weekly analysed during the sixty days preceding glycosylated haemoglobin (HbAlc) and serum scavenging capacity determination. This last parameter has been evaluated by a method based on the property of β-phycoerythrin (b-PE) to loss its fluorescence when damaged by oxygen radicals, produced by Cu" and H202. The oxygen radical absorbance capacity (ORACon) of serum was assayed as the ability to delay the loss of β-PE fluorescence. As expected, a statistically significant positive correlation was found comparing HbAlc levels with mean fasting glycaemia measured over sixty days. The key result of this study is represented by the finding that HbAlc levels show a statistically significant negative correlation with ORACou values (r=-0.26, p

Original languageEnglish
JournalBiochemical Society Transactions
Volume24
Issue number4
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Biochemistry

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