The search for susceptibility genes of COPD

M. Luisetti, P. F. Pignatti

Research output: Contribution to journalArticlepeer-review


Environmental factors, such as cigarette smoking, outdoor and indoor pollution, and childhood respiratory infections, are believed to play a major role as risk factors for developing chronic obstructive pulmonary disease (COPD), The only confirmed genetic risk factor for COPD is the inherited deficiency of α1-proteinase inhibitor. However, the evidence of familial clustering of lung function and COPD occurrence and the development of COPD among susceptile smokers, at variance with the so-called resistant smokers, would suggest that the weight of genetic risk factors is greater than recognized, In this paper the role of candidate genes for increasing the risk of COPD (such as α-proteinase inhibitor, α1-antichymotrypsin, cystic fibrosis transmembrane conductance regulator, and others) is reviewed.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalMonaldi Archives for Chest Disease - Cardiac Series
Issue number1
Publication statusPublished - 1995


  • α-antihymotrypsin
  • α-proteinase inhibitor
  • Chronic bronchitis
  • Cystic fibrosis
  • Major histocompatibility complex
  • Pulmonary emphysema

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine


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