The "second wind" in McArdle's disease patients during a second bout of constant work rate submaximal exercise

Simone Porcelli, Mauro Marzorati, Michele Belletti, Giuseppe Bellistri, Lucia Morandi, Bruno Grassi

Research output: Contribution to journalArticle

Abstract

Patients with McArdle's disease (McA) typically show the "second-wind" phenomenon, a sudden decrease in heart rate (HR) and an improved exercise tolerance occurring after a few minutes of exercise. In the present study, we investigated whether in McA a first bout of exercise determines a second wind during a second bout, separated by the first by a few minutes of recovery. Eight McA (44 ± 4 yr) and a control group of six mitochondrial myopathy patients (51 ± 6 yr) performed two repetitions (CWR1 and CWR2) of 6-min constant work rate exercise (∼50% of peak work rate) separated by 6-min (SHORT) or 18-min (LONG) recovery. Pulmonary O 2 uptake (VO2), HR, cardiac output, rates of perceived exertion, vastus lateralis oxygenation {changes in deoxygenated Hb and myoglobin Mb concentrations, A[deoxy(Hb+Mb)], by near-infrared spectroscopy} were determined. In McA, VO2 (0.86 ± 0.2 vs. 0.95 ± 0.1 l/min), HR (113 ± 10 vs. 150 ± 13 beats/min), cardiac output (11.6 ± 0.6 vs. 15.0 ± 0.8l/min), and rates of perceived exertion (11 ± 2 vs. 14 ± 3) were lower, whereas A[deoxy(Hb+Mb)] was higher (14.7 ± 2.3 vs. -0.1 ± 4.6%) in CWR2-SHORT vs. CWR1; the "overshoot" of A[deoxy(Hb+Mb)] and the "slow component" of VO2 kinetics disappeared in CWR2-SHORT. No differences (vs. CWR1) were observed in McA during CWR2-LONG, or in mitochondrial myopathy patients during both CWR2-SHORT and -LONG. A second-wind phenomenon was observed in McA during the second of two consecutive 6-min constant-work rate submaximal exercises. The second wind was associated with changes of physiological variables, suggesting an enhanced skeletal muscle oxidative metabolism. The second wind was not described after a longer (18-min) recovery period.

Original languageEnglish
Pages (from-to)1230-1237
Number of pages8
JournalJournal of Applied Physiology
Volume116
Issue number9
DOIs
Publication statusPublished - May 1 2014

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Glycogen Storage Disease Type V
Exercise
Mitochondrial Myopathies
Heart Rate
Cardiac Output
Exercise Tolerance
Near-Infrared Spectroscopy
Myoglobin
Quadriceps Muscle
Skeletal Muscle
Lung
Control Groups

Keywords

  • Exercise tolerance
  • Myophoshorylase deficiency
  • Near-infrared spectroscopy

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Medicine(all)

Cite this

The "second wind" in McArdle's disease patients during a second bout of constant work rate submaximal exercise. / Porcelli, Simone; Marzorati, Mauro; Belletti, Michele; Bellistri, Giuseppe; Morandi, Lucia; Grassi, Bruno.

In: Journal of Applied Physiology, Vol. 116, No. 9, 01.05.2014, p. 1230-1237.

Research output: Contribution to journalArticle

Porcelli, Simone ; Marzorati, Mauro ; Belletti, Michele ; Bellistri, Giuseppe ; Morandi, Lucia ; Grassi, Bruno. / The "second wind" in McArdle's disease patients during a second bout of constant work rate submaximal exercise. In: Journal of Applied Physiology. 2014 ; Vol. 116, No. 9. pp. 1230-1237.
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