Histopathological contribution to the clinical diagnosis of inflammatory skin diseases can be conditioned by the complication in obtaining skin samples from patients that are generally scared from pain and scars deriving from biopsies. Moreover, histopathological diagnosis can be difficult because of inadequate biopsies (too superficial, too little, in the wrong lesion stage) or unsatisfactory pathology report, especially when the histopathological examination lack the support of exhaustive and detailed clinical information. A concrete contribution to minimize the problems can derive from the application of RCM for evaluation of inflammatory skin processes. In particular, its and axial resolution and its noninvasive and easy clinical application represent the goals for a large diffusion of this relatively new technology not only for diagnosis and management of skin cancers but also for inflammatory skin diseases.
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