The Sentinel Project: An update on the prevalence of antimicrobial resistance in community-acquired respiratory Streptococcus pneumoniae and Haemophilus spp. in Italy

A. Marchese, F. Ardito, G. Fadda, R. Fontana, G. Lo Cascio, G. Nicoletti, A. M. Speciale, G. C. Schito

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A total of 460 Streptococcus pneumoniae and Haemophilus spp. collected from respiratory infections during 2000 was tested for their susceptibility to 15 selected antibiotics. Overall, penicillin resistance among pneumococci was 10.5%, while lack of susceptibility to macrolides, co-trimoxazole, tetracycline and chloramphenicol reached 35.2%, 26.2%, 22.6% and 6.0%, respectively. Amoxicillin/clavulanic acid and levofloxacin were the most potent compounds (100% and 99.9% susceptible strains, respectively). Among isolates of Haemophilus influenzae and Haemophilus parainfluenzae, beta-lactamase production (12.5% and 10%, respectively), and co-trimoxazole (19.9% and 40.0%) and clarithromycin (11.2% and 40.0%) resistance were the prevalent threats. This study confirms the trend observed in Italy since 1992: macrolide resistance among respiratory microorganisms is increasing, while several drugs including amoxicillin/clavulanic acid, third generation injectable cephalosporins and fluoroquinolones remain active on the great majority of these pathogens.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume26
Issue number1
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Haemophilus
Amoxicillin-Potassium Clavulanate Combination
Macrolides
Sulfamethoxazole Drug Combination Trimethoprim
Streptococcus pneumoniae
Italy
Haemophilus parainfluenzae
Penicillin Resistance
Levofloxacin
Clarithromycin
Fluoroquinolones
Haemophilus influenzae
Chloramphenicol
Cephalosporins
beta-Lactamases
Tetracycline
Respiratory Tract Infections
Anti-Bacterial Agents
Injections
Pharmaceutical Preparations

Keywords

  • Antibiotic resistance
  • Epidemiology
  • Pneumococci
  • Respiratory pathogens
  • Surveillance

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

The Sentinel Project : An update on the prevalence of antimicrobial resistance in community-acquired respiratory Streptococcus pneumoniae and Haemophilus spp. in Italy. / Marchese, A.; Ardito, F.; Fadda, G.; Fontana, R.; Lo Cascio, G.; Nicoletti, G.; Speciale, A. M.; Schito, G. C.

In: International Journal of Antimicrobial Agents, Vol. 26, No. 1, 07.2005, p. 8-12.

Research output: Contribution to journalArticle

Marchese, A. ; Ardito, F. ; Fadda, G. ; Fontana, R. ; Lo Cascio, G. ; Nicoletti, G. ; Speciale, A. M. ; Schito, G. C. / The Sentinel Project : An update on the prevalence of antimicrobial resistance in community-acquired respiratory Streptococcus pneumoniae and Haemophilus spp. in Italy. In: International Journal of Antimicrobial Agents. 2005 ; Vol. 26, No. 1. pp. 8-12.
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