The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study

M. Leone; A. Attanasio; D. Croci; G. Filippini; D. D'Amico; L. Grazzi; A. Nespolo; Gennaro Bussone

The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study

M. Leone, A. Attanasio, D. Croci, G. Filippini, D. D'Amico, L. Grazzi, A. Nespolo, Gennaro Bussone

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

In a double-blind study versus placebo, the serotonergic agent m- chlorophenylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typical migraine attacks. In the following 24-hours there were more migraines after mCPP than after placebo in both groups. These findings are consistent with involvement of 5HT(2B,2C,1A) receptor subtypes in the pathophysiology of migraine.

Original language	English
Pages (from-to)	136-139
Number of pages	4
Journal	Neurology
Volume	55
Issue number	1
Publication status	Published - Jul 12 2000

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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AU - D'Amico, D.

AU - Grazzi, L.

AU - Nespolo, A.

AU - Bussone, Gennaro

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The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study

Abstract

ASJC Scopus subject areas

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