Abstract
In a double-blind study versus placebo, the serotonergic agent m- chlorophenylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typical migraine attacks. In the following 24-hours there were more migraines after mCPP than after placebo in both groups. These findings are consistent with involvement of 5HT(2B,2C,1A) receptor subtypes in the pathophysiology of migraine.
| Original language | English |
|---|---|
| Pages (from-to) | 136-139 |
| Number of pages | 4 |
| Journal | Neurology |
| Volume | 55 |
| Issue number | 1 |
| Publication status | Published - Jul 12 2000 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
The serotonergic agent m-chlorophenylpiperazine induces migraine attacks : A controlled study. / Leone, M.; Attanasio, A.; Croci, D.; Filippini, G.; D'Amico, D.; Grazzi, L.; Nespolo, A.; Bussone, Gennaro.
In: Neurology, Vol. 55, No. 1, 12.07.2000, p. 136-139.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The serotonergic agent m-chlorophenylpiperazine induces migraine attacks
T2 - A controlled study
AU - Leone, M.
AU - Attanasio, A.
AU - Croci, D.
AU - Filippini, G.
AU - D'Amico, D.
AU - Grazzi, L.
AU - Nespolo, A.
AU - Bussone, Gennaro
PY - 2000/7/12
Y1 - 2000/7/12
N2 - In a double-blind study versus placebo, the serotonergic agent m- chlorophenylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typical migraine attacks. In the following 24-hours there were more migraines after mCPP than after placebo in both groups. These findings are consistent with involvement of 5HT(2B,2C,1A) receptor subtypes in the pathophysiology of migraine.
AB - In a double-blind study versus placebo, the serotonergic agent m- chlorophenylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typical migraine attacks. In the following 24-hours there were more migraines after mCPP than after placebo in both groups. These findings are consistent with involvement of 5HT(2B,2C,1A) receptor subtypes in the pathophysiology of migraine.
UR - http://www.scopus.com/inward/record.url?scp=0034641334&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034641334&partnerID=8YFLogxK
M3 - Article
C2 - 10891925
AN - SCOPUS:0034641334
VL - 55
SP - 136
EP - 139
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 1
ER -