The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study

M. Leone, A. Attanasio, D. Croci, G. Filippini, D. D'Amico, L. Grazzi, A. Nespolo, Gennaro Bussone

Research output: Contribution to journalArticle

Abstract

In a double-blind study versus placebo, the serotonergic agent m- chlorophenylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typical migraine attacks. In the following 24-hours there were more migraines after mCPP than after placebo in both groups. These findings are consistent with involvement of 5HT(2B,2C,1A) receptor subtypes in the pathophysiology of migraine.

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalNeurology
Volume55
Issue number1
Publication statusPublished - Jul 12 2000

ASJC Scopus subject areas

  • Neuroscience(all)

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    Leone, M., Attanasio, A., Croci, D., Filippini, G., D'Amico, D., Grazzi, L., Nespolo, A., & Bussone, G. (2000). The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study. Neurology, 55(1), 136-139.