Abstract
In a double-blind study versus placebo, the serotonergic agent m- chlorophenylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typical migraine attacks. In the following 24-hours there were more migraines after mCPP than after placebo in both groups. These findings are consistent with involvement of 5HT(2B,2C,1A) receptor subtypes in the pathophysiology of migraine.
| Original language | English |
|---|---|
| Pages (from-to) | 136-139 |
| Number of pages | 4 |
| Journal | Neurology |
| Volume | 55 |
| Issue number | 1 |
| Publication status | Published - Jul 12 2000 |
ASJC Scopus subject areas
- Neuroscience(all)
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Leone, M., Attanasio, A., Croci, D., Filippini, G., D'Amico, D., Grazzi, L., Nespolo, A., & Bussone, G. (2000). The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study. Neurology, 55(1), 136-139.