Serotonin (5-HT) and serotonin receptors play an important role in migraine pathophysiology. Changes in platelet 5-HT content are not casually related, but they may reflect similar changes at a neuronal level. Seven different classes of serotoninergic receptors are known, nevertheless only 5-HT2B-2C and 5HT1B-1D are related to migraine syndrome. Pharmacological evidences suggest that migraine is due to an hypersensitivity of 5-HT2B-2C receptors. m-Chlorophenylpiperazine (mCPP), a 5-HT2B-2C agonist, may induce migraine attacks. Moreover different pharmacological preventive therapies (pizotifen, cyproheptadine and methysergide) are antagonist of the same receptor class. On the other side the activation of 5-HT1B-1D receptors (triptans and ergotamines) induce a vasocostriction, a block of neurogenic inflammation and pain transmission.
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine