The serotonin transporter gene polymorphism STin2 VNTR confers an increased risk of inconsistent response to triptans in migraine patients

Salvatore Terrazzino, Michele Viana, Elisa Floriddia, Francesco Monaco, Daniela Mittino, Grazia Sances, Cristina Tassorelli, Giuseppe Nappi, Maurizio Rinaldi, Pier Luigi Canonico, Armando A. Genazzani

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the present observational study was to assess the value of the C825T polymorphism of the β-3 subunit of G proteins (GNB3) as well as of variants in the SLC6A4 gene (5HTTLPR and STin2 VNTR) and DRD2 gene (TaqI A and NcoI) as predictive markers for consistency in headache response to triptans in migraine patients. Consistent responders to triptans were defined as the migraineurs who experienced a ≥ 2 point reduction in a 4-point scale intensity of pain from 3 (severe) to 0 (absent) 2. h after triptan administration, in at least two attacks out of the three. Genotyping was performed by PCR and PCR-RFLP on genomic DNA extracted from peripheral blood. The impact of clinical and biological variables on consistency status of headache response to triptans was evaluated by using a binary logistic regression model with stepwise selection. Forty-three (33%) of the 130 migraine patients included in the study did not consistently respond to triptan administration. In a binary logistic regression model, STin 2.12/12 genotype (OR = 3.363, 95% CI: 1.262-8.966, P= 0.005) and non-use of migraine prophylactic medications (OR = 2.848, 95% CI: 1.019-7.959, P= 0.010) were found as significant factors increasing the odds of achieving inconsistent response to triptans. The analysis of classificatory power of the model showed moderate values of sensitivity (0.56), high specificity (0.87), and an overall prediction correctness (0.77). These results support the role of STin2 VNTR polymorphism of serotonin transporter gene as a relevant genetic factor conferring a higher risk of inconsistent response to triptans in migraine patients.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalEuropean Journal of Pharmacology
Volume641
Issue number2-3
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Consistency
  • Headache response
  • Migraine
  • Serotonin transporter
  • STin2 polymorphism
  • Triptans

ASJC Scopus subject areas

  • Pharmacology

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