The serotonin transporter promoter polymorphic region is not a risk factor for Alzheimer's disease related behavioral disturbances

Diego Albani, Francesca Prato, Mauro Tettamanti, Carlo Lovati, Daniela Galimberti, Ilaria Restelli, Claudio Mariani, Pier Luigi Quadri, Elio Scarpini, Ugo Lucca, Gianluigi Forloni

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and often accompanied during its progression by behavioral and psychological symptoms of dementia (BPSD). We decided to evaluate the association between AD-related behavioral disturbances and the short/long (S/L) polymorphism of the promoter region of the 5-hydroxytryptamine (5-HT) transporter gene (SLC6A4). This functional polymorphism modulates SLC6A4 transcription rate, with the S-allele having a 2-fold reduced efficiency, leading to a diminished availability of 5-HT that might in turn trigger behavioral and cognitive alterations. The SLC6A4 promoter functional single nucleotide polymorphism rs25531 (A→G) was genotyped as well. We collected 235 sporadic AD subjects that were classified as AD with (n = 122) or without (n = 113) behavioral alterations, assessed with the Spontaneous Behavior Interview scale, section Behavioral Problems (SBI-BP). Comparing the genotypic and allelic frequencies of AD without and with BPSD, we did not find a difference for the 5-HTTLPR or the rs25531, even after stratification according to single SBI-BP item. We conclude that 5-HTTLPR and rs25531 are not major genetic modulators of BPSD development in AD.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalJournal of Alzheimer's Disease
Volume18
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • 5-HTTLPR
  • Alzheimer's disease
  • Behavioral and psychological symptoms of dementia (BPSD)
  • Genetics
  • Rs25531
  • Serotonin
  • Serotonin transporter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Fingerprint Dive into the research topics of 'The serotonin transporter promoter polymorphic region is not a risk factor for Alzheimer's disease related behavioral disturbances'. Together they form a unique fingerprint.

Cite this