The serum levels of sE-selectin are increased in patients with bullous pemphigoid or pemphigus vulgaris. Correlation with the number of skin lesions and recovery after corsticosteroid therapy

L. D'Auria, P. Cordiali Fei, M. Pietravalle, C. Ferraro, A. Mastroianni, C. Bonifati, B. Giacalone, F. Ameglio

Research output: Contribution to journalArticle

Abstract

Soluble E (sE)-selectin represents the soluble isoform of cellular E- selectin, an adhesion molecule synthesized only by endothelial cells. As a consequence, it may be considered a marker of endothelial activity. The aim of this study was therefore to evaluate the serum levels of sE-selectin in nine patients affected with pemphigus vulgaris (PV) and in 15 patients with bullous pemphigoid (BP). Higher amounts of sE-selectin, median 40.3 ng/mL range 30-109.6 were found in the patients when compared with 20 healthy individuals, median 28.5 ng/mL range 6.4-48: P <0.01, matched for sex and age. These levels were also significantly correlated with the number of detectable lesions (r = 0.63, P <0.001) when the patient data were considered at the time of the first observation. Thirteen subjects were followed over time for a maximum of 3 months (from three to seven observations). During therapy, the number of lesions and the serum sE- selectin values decreased concomitantly. Differently from sE-selectin, the serum soluble intercellular adhesion molecule-1 (sICAM-1) values were not significantly different in the patients from the controls and showed no correlation with the serum sE-selectin concentrations or with the number of lesions. The data presented point to the possible use of sE-selectin determinations as a non-specific follow-up marker, suitable to gauge disease Intensity over time and emphasize that endothelial activation is present in BP as well as in PV.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalBritish Journal of Dermatology
Volume137
Issue number1
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'The serum levels of sE-selectin are increased in patients with bullous pemphigoid or pemphigus vulgaris. Correlation with the number of skin lesions and recovery after corsticosteroid therapy'. Together they form a unique fingerprint.

  • Cite this