The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics

Paolo Zamboni, Erica Menegatti, Bianca Weinstock-Guttman, Claudiu Schirda, Jennifer L. Cox, Anna M. Malagoni, David Hojnacki, Cheryl Kennedy, Ellen Carl, Michael G. Dwyer, Niels Bergsland, Roberto Galeotti, Sara Hussein, Ilaria Bartolomei, Fabrizio Salvi, Robert Zivadinov

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular picture that shows a strong association with multiple sclerosis (MS). The aim of this study was to investigate the relationship between a Doppler cerebral venous hemodynamic Insufficiency severity score (VHISS) and cerebrospinal fluid (CSF) flow dynamics in 16 patients presenting with CCSVI and relapsing-remitting MS (CCSVI-MS) and in eight healthy controls (HCs). The two groups (patients and controls) were evaluated using validated echo-Doppler and advanced 3T-MRI CSF flow measures. Compared with the HCs, the CCSVI-MS patients showed a significantly lower net CSF flow (p=0.027) which was highly associated with the VHISS (r=0.8280, r2=0.6855; p=0.0001). This study demonstrates that venous outflow disturbances In the form of CCSVI significantly impact on CSF pathophysiology in patients with MS.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalFunctional Neurology
Volume24
Issue number3
Publication statusPublished - 2009

Keywords

  • CCSVI
  • Chronic cerebrospinal venous insufficiency
  • CSF
  • Echo-Doppler
  • MRI
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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