The SF-36 instrument for the follow-up of health-related quality-of-life assessment of patients undergoing home parenteral nutrition for benign disease

L. Pironi, F. Paganelli, P. Mosconi, A. M. Morselli-Labate, G. Spinucci, C. Merli, M. Guidetti, M. Miglioli

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction The non-disease-specific SF-36 instrument was applied to detect changes in quality of life among patients at a single center who were receiving home parenteral nutrition (HPN) for intestinal failure. Methods All HPN patients completed the questionnaire during routine visits. The SF-36 examines eight domains (scores: 0% to 100%): physical functioning (PF), role-functioning physical (RP), body pain (BP), general health (GH), vitality (VT), social functioning (SF), as well as role-functioning emotional (RE) and mental health (MH). Patient responses were standardized for the sex- and age-matched group scores of the healthy population by calculating the Z-score: (healthy population mean score - patient raw score)/healthy population standard deviation (reduced value: Z-score <-1). A difference in a domain score was considered significant in the individual patient if it was greater than the 90% confidence interval for healthy subjects and if it produced a change in Z-score category. General, sociodemographic, underlying disease and HPN-related factors were collected. Results For 31 enrolled adult patients, the baseline mean Z-score was reduced in five domains: PF, RP, BP, GH and SF. Twenty patients underwent a second SF-36 assessment 10 ± 2 months later: the HRQOL worsened in eight and improved in 10 (no. worsened domains > no. improved or vice versa). The worsened subgroup showed a decrease in body mass index (P = .104), an increase in the number of HPN infusions per week (P = .065), and a greater incidence of intestinal motility disorders (P = .161), of liquid oral diet (P = .027), and of nycturia (P = .028). Conclusions The SF-36 instrument reflecting the generic HRQOL assessment may be a suitable tool for patients on HPN.

Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalTransplantation Proceedings
Volume36
Issue number2
DOIs
Publication statusPublished - Mar 2004

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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