TY - JOUR
T1 - The shape of motor resonance
T2 - Right- or left-handed?
AU - Cabinio, Monia
AU - Blasi, Valeria
AU - Borroni, Paola
AU - Montagna, Marcella
AU - Iadanza, Antonella
AU - Falini, Andrea
AU - Cerri, Gabriella
PY - 2010/5
Y1 - 2010/5
N2 - The human mirror neuron system is a fronto-parietal neural pathway which, when activated by action observation, gives rise to an internal simulation of the observed action (motor resonance). Here we demonstrate how handedness shapes the resonant response, by engaging right-handed (RH) and left-handed (LH) subjects in observation and execution of actions preferentially performed by the dominant hand. We hypothesize that since motor resonance reproduces subliminally the specific motor program for the observed action, it should be subject to motor constraints, such as handedness. A conjunction analysis for observed and executed actions revealed that handedness determines a lateralized activation of the areas engaged in motor resonance. Premotor-BA6 and parietal-BA40 are strongly left lateralized in RH subjects observing or moving their right hand, and to a lesser degree their left hand. Extremely LH subjects show a similar pattern of lateralization on the right, while more ambidextrous LH subjects show a more bilateral activation. The activation of a cortical network outside the mirror neuron system is also discussed.
AB - The human mirror neuron system is a fronto-parietal neural pathway which, when activated by action observation, gives rise to an internal simulation of the observed action (motor resonance). Here we demonstrate how handedness shapes the resonant response, by engaging right-handed (RH) and left-handed (LH) subjects in observation and execution of actions preferentially performed by the dominant hand. We hypothesize that since motor resonance reproduces subliminally the specific motor program for the observed action, it should be subject to motor constraints, such as handedness. A conjunction analysis for observed and executed actions revealed that handedness determines a lateralized activation of the areas engaged in motor resonance. Premotor-BA6 and parietal-BA40 are strongly left lateralized in RH subjects observing or moving their right hand, and to a lesser degree their left hand. Extremely LH subjects show a similar pattern of lateralization on the right, while more ambidextrous LH subjects show a more bilateral activation. The activation of a cortical network outside the mirror neuron system is also discussed.
KW - FMRI
KW - Handedness
KW - Mirror neurons
UR - http://www.scopus.com/inward/record.url?scp=77950532875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950532875&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2010.01.103
DO - 10.1016/j.neuroimage.2010.01.103
M3 - Article
C2 - 20132891
AN - SCOPUS:77950532875
VL - 51
SP - 313
EP - 323
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 1
ER -