The "Sharp" blade against HIF-mediated metastasis

Ivano Amelio, Gerry Melino

Research output: Contribution to journalArticlepeer-review


Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and mobility. HIFs overexpression in human cancer biopsies correlates with high metastasis and mortality. A recent report has elucidated a novel mechanism for HIFs regulation in triple-negative breast cancer. Specifically, the basic helix-loop-helix (bHLH), Sharp-1, serves HIF1á to the proteasome and promotes its O2-indendpendet degradation, counteracting HIF-mediated metastasis. These findings shed light on how HIFs are manipulated during cancer pathogenesis.

Original languageEnglish
Pages (from-to)4530-4535
Number of pages6
JournalCell Cycle
Issue number24
Publication statusPublished - Dec 15 2012


  • Angiogenesis
  • Breast cancer
  • Cancer metabolism
  • HIF
  • Hypoxia
  • Metastasis
  • p63
  • Sharp1
  • VHL

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology


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