Abstract
Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and mobility. HIFs overexpression in human cancer biopsies correlates with high metastasis and mortality. A recent report has elucidated a novel mechanism for HIFs regulation in triple-negative breast cancer. Specifically, the basic helix-loop-helix (bHLH), Sharp-1, serves HIF1á to the proteasome and promotes its O2-indendpendet degradation, counteracting HIF-mediated metastasis. These findings shed light on how HIFs are manipulated during cancer pathogenesis.
Original language | English |
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Pages (from-to) | 4530-4535 |
Number of pages | 6 |
Journal | Cell Cycle |
Volume | 11 |
Issue number | 24 |
DOIs | |
Publication status | Published - Dec 15 2012 |
Keywords
- Angiogenesis
- Breast cancer
- Cancer metabolism
- HIF
- Hypoxia
- Metastasis
- p63
- Sharp1
- VHL
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Developmental Biology