The shifting paradigm of prognostic factors of colorectal liver metastases: From tumor-centered to host immune-centered factors

Research output: Contribution to journalReview article

Abstract

The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.

Original languageEnglish
Article number181
JournalFrontiers in Oncology
Volume8
Issue numberMAY
DOIs
Publication statusPublished - May 28 2018

Keywords

  • Colorectal cancer
  • Colorectal cancer liver metastases
  • Colorectal liver metastases
  • Host immune system
  • Immune response
  • Immunotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The shifting paradigm of prognostic factors of colorectal liver metastases: From tumor-centered to host immune-centered factors'. Together they form a unique fingerprint.

  • Cite this