Abstract
The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.
| Original language | English |
|---|---|
| Article number | 181 |
| Journal | Frontiers in Oncology |
| Volume | 8 |
| Issue number | MAY |
| DOIs | |
| Publication status | Published - May 28 2018 |
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Keywords
- Colorectal cancer
- Colorectal cancer liver metastases
- Colorectal liver metastases
- Host immune system
- Immune response
- Immunotherapy
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
The shifting paradigm of prognostic factors of colorectal liver metastases : From tumor-centered to host immune-centered factors. / Donadon, Matteo; Lleo, Ana; Di Tommaso, Luca; Soldani, Cristiana; Franceschini, Barbara; Roncalli, Massimo; Torzilli, Guido.
In: Frontiers in Oncology, Vol. 8, No. MAY, 181, 28.05.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The shifting paradigm of prognostic factors of colorectal liver metastases
T2 - From tumor-centered to host immune-centered factors
AU - Donadon, Matteo
AU - Lleo, Ana
AU - Di Tommaso, Luca
AU - Soldani, Cristiana
AU - Franceschini, Barbara
AU - Roncalli, Massimo
AU - Torzilli, Guido
PY - 2018/5/28
Y1 - 2018/5/28
N2 - The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.
AB - The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.
KW - Colorectal cancer
KW - Colorectal cancer liver metastases
KW - Colorectal liver metastases
KW - Host immune system
KW - Immune response
KW - Immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=85047666516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047666516&partnerID=8YFLogxK
U2 - 10.3389/fonc.2018.00181
DO - 10.3389/fonc.2018.00181
M3 - Review article
AN - SCOPUS:85047666516
VL - 8
JO - Frontiers in Oncology
JF - Frontiers in Oncology
SN - 2234-943X
IS - MAY
M1 - 181
ER -