The shifting paradigm of prognostic factors of colorectal liver metastases

From tumor-centered to host immune-centered factors

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.

Original languageEnglish
Article number181
JournalFrontiers in Oncology
Volume8
Issue numberMAY
DOIs
Publication statusPublished - May 28 2018

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Immunologic Factors
Neoplasm Metastasis
Liver
Immune System
Neoplasms
Genetic Markers
Colorectal Neoplasms
Biomarkers

Keywords

  • Colorectal cancer
  • Colorectal cancer liver metastases
  • Colorectal liver metastases
  • Host immune system
  • Immune response
  • Immunotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "The shifting paradigm of prognostic factors of colorectal liver metastases: From tumor-centered to host immune-centered factors",
abstract = "The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.",
keywords = "Colorectal cancer, Colorectal cancer liver metastases, Colorectal liver metastases, Host immune system, Immune response, Immunotherapy",
author = "Matteo Donadon and Ana Lleo and {Di Tommaso}, Luca and Cristiana Soldani and Barbara Franceschini and Massimo Roncalli and Guido Torzilli",
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T1 - The shifting paradigm of prognostic factors of colorectal liver metastases

T2 - From tumor-centered to host immune-centered factors

AU - Donadon, Matteo

AU - Lleo, Ana

AU - Di Tommaso, Luca

AU - Soldani, Cristiana

AU - Franceschini, Barbara

AU - Roncalli, Massimo

AU - Torzilli, Guido

PY - 2018/5/28

Y1 - 2018/5/28

N2 - The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.

AB - The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.

KW - Colorectal cancer

KW - Colorectal cancer liver metastases

KW - Colorectal liver metastases

KW - Host immune system

KW - Immune response

KW - Immunotherapy

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