Il sigh nell'ARDS. (Acute Respiratory Distress Syndrome).

Translated title of the contribution: The sigh in ARDS (acute respiratory distress syndrome)

P. Pelosi, N. Bottino, M. Panigada, G. Eccher, L. Gattinoni

Research output: Contribution to journalArticlepeer-review


We studied 10 consecutive, sedated and paralyzed patients with Acute Respiratory Distress Syndrome (ARDS). The entire study lasted 4 hours, divided in 3 periods: 2 hours of recommended ventilation [lung protective strategy, LPS, i.e., ventilation with low tidal volume (<8 mL/kg), limiting the plateau at 35 cm H2O, together with high positive end-expiratory pressure (PEEP)], 1 hour of sigh (LPS with 3 consecutive sighs/min at 45 cm H2O plateau pressure), and 1 hour of LPS. Total minute ventilation, PEEP, FiO2 and mean airway pressure were kept constant. The introduction of sighs induced a consistent recruitment and PaO2 improvement, and a decrease in venous admixture and PaCO2. Interrupting sighs and resuming LPS led to a progressive derecruitment, and all the physiological variables returned to baseline. Derecruitment was higher in patients with higher PaCO2 and lower VA/Q ratio. We conclude that: 1) LPS alone does not provide full lung recruitment and best oxygenation in ARDS; 2) application of sigh may provide pressure enough to recruit and volume enough to prevent reabsorption atelectasis.

Translated title of the contributionThe sigh in ARDS (acute respiratory distress syndrome)
Original languageItalian
Pages (from-to)313-317
Number of pages5
JournalMinerva Anestesiologica
Issue number5
Publication statusPublished - May 1999

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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