The significance of left ventricular ejection time in heart failure with reduced ejection fraction

Alia S. Alhakak, John R. Teerlink, Joann Lindenfeld, Michael Böhm, Giuseppe M.C. Rosano, Tor Biering-Sørensen

Research output: Contribution to journalReview articlepeer-review

Abstract

Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood into the aorta. LVET has been used for several decades to assess left ventricular function and contractility. However, there is a recent interest in LVET as a measure of therapeutic action for novel drugs in patients with heart failure with reduced ejection fraction (HFrEF), since LVET is shortened in these patients. This review provides an overview of the available information on LVET including methods of measuring LVET, mechanistic understanding of LVET, association of LVET with outcomes, mechanisms behind shortened LVET in HFrEF and the potential implications of drugs that affect and normalize LVET.

Original languageEnglish
JournalEuropean Journal of Heart Failure
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Contractility
  • Heart failure
  • Left ventricular ejection time
  • Myotropes
  • Outcomes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'The significance of left ventricular ejection time in heart failure with reduced ejection fraction'. Together they form a unique fingerprint.

Cite this