The significance of mannose-binding lectin gene polymorphisms on the risk of BK virus coinfection in women with human papillomavirus-positive cervical lesions

Manola Comar, Ludovica Segat, Sergio Crovella, Massimo Bovenzi, Enzo Cortini, Mauro Tognon

Research output: Contribution to journalArticlepeer-review

Abstract

The simultaneous detection of oncogenic human papillomavirus (HPV) and BK virus (BKV) has been recently reported in cervical cancers, suggesting that these viruses may act together in the process of cell transformation; host genetic polymorphisms may also influence virus persistence/reactivation. To disclose a possible role of the gene encoding for the mannose-binding lectin, MBL2, in susceptibility to BKV infection, we analyzed functional polymorphisms in the first exon of MBL2 in women stratified for the presence/absence of BKV and affected by different grades of HPV-induced cervical precancerous lesions. All BKV-positive samples were also HPV positive (HPV 16), and all presented with high-grade squamous intraepithelial lesions. The MBL2 A allele was significantly more frequent in BKV-negative patients than in BKV-positive patients. These data indicate a possible role for the A allele in conferring protection to BKV infection in high-risk HPV-positive women (odds ratio 0.40, 95% confidence interval 0.20-0.85, p = 0.01).

Original languageEnglish
Pages (from-to)663-666
Number of pages4
JournalHuman Immunology
Volume72
Issue number8
DOIs
Publication statusPublished - Aug 2011

Keywords

  • BKV
  • HPV
  • HSIL
  • LSIL
  • Mannose-binding lectin
  • MBL2

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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