L'importanza del controllo della variabilità glicemica nella prevenzione delle complicanze del paziente con diabete mellito

Achieving adequate targets relatively to all risk factors is now considered a standard of care for diabetes. It's well-known that optimising glycemic control represents one of the most difficult objectives. Several literature data showed that optimising glycemic control needs achieving a control of circadian glycemic levels and of its variations. The objective of the present work is reviewing data from clinical and experimental research in order to support the relevance of both pathogenetic mechanisms and clinical control of circadian glycemic variation; this latter objective may be achieved by an accurate knowledge of circadian glycemic variation, which could be measured at home. Self monitoring blood glucose level test should be performed according to specific modalities and the results should be elaborated by specific softwares, which are able to generate summarizing data. Besides, predictive indexes of glycemic variations could be obtained from these data thus optimising therapeutic management with targeted treatments.