The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes

Antonio Ceriello, Valeria De Nigris, Gemma Pujadas, Lucia La Sala, Anna Rita Bonfigli, Roberto Testa, Annachiara Uccellatore, Stefano Genovese

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To test the effect of normoglycemia and glucagon-like peptide-1 (GLP-1), alone or in combination, on the possible normalization of endothelial function in type 1 diabetes. Methods: Fifteen people with type 1 diabetes participated in three experiments: reaching and maintaining normoglycemia for 4 h; reaching and maintaining hyperglycemia plus GLP-1 infusion for 4 h; and reaching and maintaining normoglycemia for 4 h with simultaneous infusion of GLP-1. Results: Both normoglycemia and GLP-1 infusion restored endothelial function and decreased and plasma 8-iso prostaglandin F2α levels. However, only the combination of normoglycemia and GLP-1 was able to normalize endothelial function. Conclusions: This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalDiabetes Research and Clinical Practice
Volume114
DOIs
Publication statusPublished - Apr 1 2016

Keywords

  • Endothelial function
  • GLP-1
  • Metabolic memory
  • Oxidative stress
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

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