The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes

Antonio Ceriello, Valeria De Nigris, Gemma Pujadas, Lucia La Sala, Anna Rita Bonfigli, Roberto Testa, Annachiara Uccellatore, Stefano Genovese

Research output: Contribution to journalArticle

Abstract

Background: To test the effect of normoglycemia and glucagon-like peptide-1 (GLP-1), alone or in combination, on the possible normalization of endothelial function in type 1 diabetes. Methods: Fifteen people with type 1 diabetes participated in three experiments: reaching and maintaining normoglycemia for 4 h; reaching and maintaining hyperglycemia plus GLP-1 infusion for 4 h; and reaching and maintaining normoglycemia for 4 h with simultaneous infusion of GLP-1. Results: Both normoglycemia and GLP-1 infusion restored endothelial function and decreased and plasma 8-iso prostaglandin F2α levels. However, only the combination of normoglycemia and GLP-1 was able to normalize endothelial function. Conclusions: This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalDiabetes Research and Clinical Practice
Volume114
DOIs
Publication statusPublished - Apr 1 2016

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Glucagon-Like Peptide 1
Type 1 Diabetes Mellitus
Hyperglycemia
Dinoprost

Keywords

  • Endothelial function
  • GLP-1
  • Metabolic memory
  • Oxidative stress
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

Cite this

The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes. / Ceriello, Antonio; De Nigris, Valeria; Pujadas, Gemma; La Sala, Lucia; Bonfigli, Anna Rita; Testa, Roberto; Uccellatore, Annachiara; Genovese, Stefano.

In: Diabetes Research and Clinical Practice, Vol. 114, 01.04.2016, p. 64-68.

Research output: Contribution to journalArticle

Ceriello, Antonio ; De Nigris, Valeria ; Pujadas, Gemma ; La Sala, Lucia ; Bonfigli, Anna Rita ; Testa, Roberto ; Uccellatore, Annachiara ; Genovese, Stefano. / The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes. In: Diabetes Research and Clinical Practice. 2016 ; Vol. 114. pp. 64-68.
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AU - Testa, Roberto

AU - Uccellatore, Annachiara

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