The simultaneous occurrence of cytoplasmic receptors for steroid hormones in normal and pathological female breast tissues

G. Nicoletti, M. C. Galli, C. De Giovanni

Research output: Contribution to journalArticle


The cytoplasmic receptors for estradiol-17β, dihydrotestosterone-5α, progesterone and cortisol were quantitated in 181 specimens of normal and pathological female breast tissue by means of a dextran-coated charcoal technique. With the value of 3 fmoles/mg protein as the cutoff point between high and low binding capacity, the simultaneous occurrence of all four receptors in specimens from malignant breast tissue ranged 25% and 50%, whereas the cases which presented both estradiol and progesterone receptors were: 40% to 62% in malignant lesions; 16% in normal tissue. Within each single bioptic group either the occurrence and concentration of estradiol receptor (ER) were directly correlated with those of progesterone receptor (PR): ER-PR+ cases were 3.1%. Such a relationship was also observed when all specimens were considered as a whole. However, among the 10 cases where the receptor pattern of the metastatic tissue was compared to that of the relative primary cancer, 4 cases showed differences in the patterns of estradiol and progesterone receptors.

Original languageEnglish
Pages (from-to)445-446
Number of pages2
JournalIRCS Medical Science
Issue number5
Publication statusPublished - 1981


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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