The cytoplasmic receptors for estradiol-17β, dihydrotestosterone-5α, progesterone and cortisol were quantitated in 181 specimens of normal and pathological female breast tissue by means of a dextran-coated charcoal technique. With the value of 3 fmoles/mg protein as the cutoff point between high and low binding capacity, the simultaneous occurrence of all four receptors in specimens from malignant breast tissue ranged 25% and 50%, whereas the cases which presented both estradiol and progesterone receptors were: 40% to 62% in malignant lesions; 16% in normal tissue. Within each single bioptic group either the occurrence and concentration of estradiol receptor (ER) were directly correlated with those of progesterone receptor (PR): ER-PR+ cases were 3.1%. Such a relationship was also observed when all specimens were considered as a whole. However, among the 10 cases where the receptor pattern of the metastatic tissue was compared to that of the relative primary cancer, 4 cases showed differences in the patterns of estradiol and progesterone receptors.
|Number of pages||2|
|Journal||IRCS Medical Science|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)