The simultaneous occurrence of cytoplasmic receptors for various steroid hormones in male breast carcinoma and gynaecomastia

S. Grilli, C. De Giovanni, M. C. Galli, L. D'Alessandro, C. Tagariello, A. Grassigli, G. Paparopoli, P. Nanni, G. Nicoletti, G. Prodi

Research output: Contribution to journalArticlepeer-review

Abstract

Using a dextran-coated charcoal (DCC) technique, the cytoplasmic receptors for estradiol-17β, dihydrotestosterone-5α(DHT), progesterone and cortisol have been quantified in 14 cases of male gynaecomastia, and in two cases of male breast cancer. Estradiol-17β and progesterone receptors were found to be present in both cases of male breast cancer when the values of 3 fmol/mg protein and 0.03 fmol/μg DNA were chosen as the cutoff points between high and low binding capacity. In gynaecomastic tissue, the occurrence of steroid hormone receptors was the following: estradiol-17β 75%, DHT 73%, progesterone 14% and cortisol 100% of the cases tested. The pattern of estradiol-17β and progesterone receptors found in gynaecomastic specimens was similar to that observed in normal female breast and in fibroadenoma: however, the single and simultaneous occurrence of these receptors were lower in the male gynaecomastic group than in female cystic disease and breast cancer tissues.

Original languageEnglish
Pages (from-to)813-820
Number of pages8
JournalJournal of Steroid Biochemistry
Volume13
Issue number7
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Fingerprint Dive into the research topics of 'The simultaneous occurrence of cytoplasmic receptors for various steroid hormones in male breast carcinoma and gynaecomastia'. Together they form a unique fingerprint.

Cite this