TY - JOUR
T1 - The simultaneous occurrence of cytoplasmic receptors for various steroid hormones in male breast carcinoma and gynaecomastia
AU - Grilli, S.
AU - De Giovanni, C.
AU - Galli, M. C.
AU - D'Alessandro, L.
AU - Tagariello, C.
AU - Grassigli, A.
AU - Paparopoli, G.
AU - Nanni, P.
AU - Nicoletti, G.
AU - Prodi, G.
PY - 1980
Y1 - 1980
N2 - Using a dextran-coated charcoal (DCC) technique, the cytoplasmic receptors for estradiol-17β, dihydrotestosterone-5α(DHT), progesterone and cortisol have been quantified in 14 cases of male gynaecomastia, and in two cases of male breast cancer. Estradiol-17β and progesterone receptors were found to be present in both cases of male breast cancer when the values of 3 fmol/mg protein and 0.03 fmol/μg DNA were chosen as the cutoff points between high and low binding capacity. In gynaecomastic tissue, the occurrence of steroid hormone receptors was the following: estradiol-17β 75%, DHT 73%, progesterone 14% and cortisol 100% of the cases tested. The pattern of estradiol-17β and progesterone receptors found in gynaecomastic specimens was similar to that observed in normal female breast and in fibroadenoma: however, the single and simultaneous occurrence of these receptors were lower in the male gynaecomastic group than in female cystic disease and breast cancer tissues.
AB - Using a dextran-coated charcoal (DCC) technique, the cytoplasmic receptors for estradiol-17β, dihydrotestosterone-5α(DHT), progesterone and cortisol have been quantified in 14 cases of male gynaecomastia, and in two cases of male breast cancer. Estradiol-17β and progesterone receptors were found to be present in both cases of male breast cancer when the values of 3 fmol/mg protein and 0.03 fmol/μg DNA were chosen as the cutoff points between high and low binding capacity. In gynaecomastic tissue, the occurrence of steroid hormone receptors was the following: estradiol-17β 75%, DHT 73%, progesterone 14% and cortisol 100% of the cases tested. The pattern of estradiol-17β and progesterone receptors found in gynaecomastic specimens was similar to that observed in normal female breast and in fibroadenoma: however, the single and simultaneous occurrence of these receptors were lower in the male gynaecomastic group than in female cystic disease and breast cancer tissues.
UR - http://www.scopus.com/inward/record.url?scp=0019201105&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019201105&partnerID=8YFLogxK
U2 - 10.1016/0022-4731(80)90234-4
DO - 10.1016/0022-4731(80)90234-4
M3 - Article
C2 - 6774173
AN - SCOPUS:0019201105
VL - 13
SP - 813
EP - 820
JO - Journal of Steroid Biochemistry
JF - Journal of Steroid Biochemistry
SN - 0022-4731
IS - 7
ER -