The sixth sense

Hematopoietic stem cells detect danger through purinergic signaling

Lara Rossi, Valentina Salvestrini, Davide Ferrari, Francesco Di Virgilio, Roberto M. Lemoli

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Over the past decade, extracellular nucleotides (such as ATP and UTP) have emerged as key immunomodulators. This family of molecules, already known for its key metabolic functions, has been the focus of intense investigation that has unambiguously shown its crucial role as mediators of cell-to-cell communication. More recently, in addition to its involvement in inflammation and immunity, purinergic signaling has also been shown to modulate BM-derived stem cells. Extracellular nucleotides promote proliferation, CXCL12-driven migration, andBMengraftment of hematopoietic progenitor and stem cells. In addition, purinergic signaling acts indirectly on hematopoietic progenitor and stem cells by regulating differentiation and release of proinflammatory cytokines in BM-derived human mesenchymal stromal cells, which are part of the hematopoietic stem cell (HSC) niche. HSC research has recently blended into the field of immunology, as new findings highlighted the role played by immunologic signals (such as IFN-α, IFN-γ, or TNF-α) in the regulation of the HSC compartment. In this review, we summarize recent reports unveiling a previously unsuspected ability of HSCs to integrate inflammatory signals released by immune and stromal cells, with particular emphasis on the dual role of extracellular nucleotides as mediators of both immunologic responses and BM stem cell functions.

Original languageEnglish
Pages (from-to)2365-2375
Number of pages11
JournalBlood
Volume120
Issue number12
DOIs
Publication statusPublished - Sep 20 2012

Fingerprint

Hematopoietic Stem Cells
Stem cells
Nucleotides
Stem Cells
Immunology
Stem Cell Niche
Stem Cell Research
Uridine Triphosphate
Immunologic Factors
Stromal Cells
Allergy and Immunology
Mesenchymal Stromal Cells
Cell Communication
Cell Differentiation
Immunity
Adenosine Triphosphate
Cytokines
Inflammation
Molecules
Communication

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

The sixth sense : Hematopoietic stem cells detect danger through purinergic signaling. / Rossi, Lara; Salvestrini, Valentina; Ferrari, Davide; Di Virgilio, Francesco; Lemoli, Roberto M.

In: Blood, Vol. 120, No. 12, 20.09.2012, p. 2365-2375.

Research output: Contribution to journalArticle

Rossi, L, Salvestrini, V, Ferrari, D, Di Virgilio, F & Lemoli, RM 2012, 'The sixth sense: Hematopoietic stem cells detect danger through purinergic signaling', Blood, vol. 120, no. 12, pp. 2365-2375. https://doi.org/10.1182/blood-2012-04-422378
Rossi, Lara ; Salvestrini, Valentina ; Ferrari, Davide ; Di Virgilio, Francesco ; Lemoli, Roberto M. / The sixth sense : Hematopoietic stem cells detect danger through purinergic signaling. In: Blood. 2012 ; Vol. 120, No. 12. pp. 2365-2375.
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