The soluble inteuleukin-2 receptor as an indicator of clinical evolution in patients with ulcerative colitis

Antonio Balzano, Antonio Bove, Enrico Leonardi, Nazario Bevilacqua, Giovanni Grande, Paolo A. Ascierto, Giuseppe Castello

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/aims: The soluble interleukin-2 receptor is a useful, non-specific marker of in-vivo activated cellular immune functions. The aim of this study was to evaluate the correlation between this marker and clinical evolution of ulcerative colitis. Methods: Serum soluble interleukin-2 receptor levels were determined, by an enzyme immune assay, in 105 patients affected by ulcerative colitis with different extent and activity of disease. Forty-six of these patients were restaged in a follow-up study, and their serum-soluble interleukin-2 receptor concentrations were measured again. Results: Serum soluble interleukin-2 receptor level is higher in pan-ulcerative colitis than in left ulcerative colitis (P = 0.050) and much higher in active than in quiescent stage of disease (P = 0.029). Clinical relapse of disease is accompanied by a serum soluble interleukin-2 receptor rise (P = 0.0697), whereas clinical and histological improvement in disease is accompanied by its significant decrease (P = 0.0009). Conclusion: In ulcerative colitis the serum determination of soluble interleukin-2 receptor is a useful and non-invasive marker of activity, and also extension and evolution of the disease.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume9
Issue number2
Publication statusPublished - 1997

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Interleukin-2 Receptors
Ulcerative Colitis
Serum
Enzyme Assays
Biomarkers
Recurrence

Keywords

  • Soluble interleukin-2 receptor
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The soluble inteuleukin-2 receptor as an indicator of clinical evolution in patients with ulcerative colitis. / Balzano, Antonio; Bove, Antonio; Leonardi, Enrico; Bevilacqua, Nazario; Grande, Giovanni; Ascierto, Paolo A.; Castello, Giuseppe.

In: European Journal of Gastroenterology and Hepatology, Vol. 9, No. 2, 1997, p. 173-177.

Research output: Contribution to journalArticle

Balzano, Antonio ; Bove, Antonio ; Leonardi, Enrico ; Bevilacqua, Nazario ; Grande, Giovanni ; Ascierto, Paolo A. ; Castello, Giuseppe. / The soluble inteuleukin-2 receptor as an indicator of clinical evolution in patients with ulcerative colitis. In: European Journal of Gastroenterology and Hepatology. 1997 ; Vol. 9, No. 2. pp. 173-177.
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AU - Grande, Giovanni

AU - Ascierto, Paolo A.

AU - Castello, Giuseppe

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