The soluble pattern recognition receptor pentraxin-3 in innate immunity, inflammation and fertility

Cecilia Garlanda, Virginia Maina, Alessia Cotena, Federica Moalli

Research output: Contribution to journalArticlepeer-review

Abstract

The innate immune system consists of a cellular and a humoral arm. Components of humoral immunity include diverse molecular families, which represent functional ancestors of antibodies. They play key roles as effectors and modulators of innate resistance and inflammation. The long pentraxin PTX3 represents a prototype humoral effector molecule. Gene targeting of this evolutionarily conserved long pentraxin has unequivocally defined its role at the crossroads of innate immunity, inflammation, matrix deposition and female fertility. Here, we will review the studies on PTX3, which emphasize its role as a multifunctional soluble pattern recognition receptor acting as a non-redundant component of the humoral arm of innate immunity involved in fine-tuning inflammation, matrix deposition, angiogenesis and, in particular, in female fertility.

Original languageEnglish
Pages (from-to)128-133
Number of pages6
JournalJournal of Reproductive Immunology
Volume83
Issue number1-2
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Fertility
  • Inflammation
  • Innate immunity
  • Pentraxin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine

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