This study investigated how 5′-UTR of DEFB1 gene (encoding for the human β-defensin-1) affects mRNA secondary structure and its correlation with translation efficiency in the susceptibility of diseases. It was possible to determine DEFB1 mRNA folding under the influence of 5′-UTR SNPs haplotypes and putative alternative transcript lengths. Different DEFB1 mRNAs that fold in a pattern that is haplotype and length-dependent are potentially able to drive changes in peptide expression dynamics.
- Alternative transcription initiation
- Regulation of gene expression
- RNA secondary structure
ASJC Scopus subject areas
- Immunology and Allergy