The sound of silence: Human β-defensin-1 gene untranslated SNPs change the predicted mRNA secondary structure in a length-dependent manner

M. S. Naslavsky, S. Crovella, J. L Lima Filho, C. R C Rocha

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated how 5′-UTR of DEFB1 gene (encoding for the human β-defensin-1) affects mRNA secondary structure and its correlation with translation efficiency in the susceptibility of diseases. It was possible to determine DEFB1 mRNA folding under the influence of 5′-UTR SNPs haplotypes and putative alternative transcript lengths. Different DEFB1 mRNAs that fold in a pattern that is haplotype and length-dependent are potentially able to drive changes in peptide expression dynamics.

Original languageEnglish
Pages (from-to)53-55
Number of pages3
JournalImmunology Letters
Volume129
Issue number1
DOIs
Publication statusPublished - Mar 10 2010

Keywords

  • Alternative transcription initiation
  • DEFB1
  • Regulation of gene expression
  • RNA secondary structure

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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