The spread of CTX-M-type extended-spectrum β-lactamases

G. M. Rossolini, M. M. D'Andrea, C. Mugnaioli

Research output: Contribution to journalArticlepeer-review


CTX-M-type enzymes are a group of classA extended-spectrum β-lactamases (ESBLs) that are rapidly spreading among Enterobacteriaceae worldwide. More that 50 allotypes are known, clustered into six sub-lineages. The CTX-M-encoding genes have been captured from the chromosome of Kluyvera spp. on conjugative plasmids that mediate their dissemination among pathogenic enterobacteria. CTX-M-type ESBLs exhibit powerful activity against cefotaxime and ceftriaxone but generally not against ceftazidime, which has important implications for laboratory detection. However, several CTX-M variants with enhanced ceftazidimase activity have been detected. The rapid and massive spread of CTX-M-type ESBLs is rapidly changing the ESBL epidemiology and, in some geographical areas, these enzymes are now the most prevalent ESBLs in Enterobacteriaceae.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalClinical Microbiology and Infection
Issue numberSUPPL. 1
Publication statusPublished - Jan 2008


  • CTX-M
  • Enterobacteriaceae
  • Epidemiology
  • Extended-spectrum b-lactamase
  • Review

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology


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