The spread of CTX-M-type extended-spectrum β-lactamases

G. M. Rossolini, M. M. D'Andrea, C. Mugnaioli

Research output: Contribution to journalArticle

Abstract

CTX-M-type enzymes are a group of classA extended-spectrum β-lactamases (ESBLs) that are rapidly spreading among Enterobacteriaceae worldwide. More that 50 allotypes are known, clustered into six sub-lineages. The CTX-M-encoding genes have been captured from the chromosome of Kluyvera spp. on conjugative plasmids that mediate their dissemination among pathogenic enterobacteria. CTX-M-type ESBLs exhibit powerful activity against cefotaxime and ceftriaxone but generally not against ceftazidime, which has important implications for laboratory detection. However, several CTX-M variants with enhanced ceftazidimase activity have been detected. The rapid and massive spread of CTX-M-type ESBLs is rapidly changing the ESBL epidemiology and, in some geographical areas, these enzymes are now the most prevalent ESBLs in Enterobacteriaceae.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalClinical Microbiology and Infection
Volume14
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Enterobacteriaceae
Kluyvera
Ceftazidime
Cefotaxime
Ceftriaxone
Enzymes
Epidemiology
Plasmids
Chromosomes
Genes

Keywords

  • CTX-M
  • Enterobacteriaceae
  • Epidemiology
  • Extended-spectrum b-lactamase
  • Review

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

The spread of CTX-M-type extended-spectrum β-lactamases. / Rossolini, G. M.; D'Andrea, M. M.; Mugnaioli, C.

In: Clinical Microbiology and Infection, Vol. 14, No. SUPPL. 1, 01.2008, p. 33-41.

Research output: Contribution to journalArticle

Rossolini, GM, D'Andrea, MM & Mugnaioli, C 2008, 'The spread of CTX-M-type extended-spectrum β-lactamases', Clinical Microbiology and Infection, vol. 14, no. SUPPL. 1, pp. 33-41. https://doi.org/10.1111/j.1469-0691.2007.01867.x
Rossolini, G. M. ; D'Andrea, M. M. ; Mugnaioli, C. / The spread of CTX-M-type extended-spectrum β-lactamases. In: Clinical Microbiology and Infection. 2008 ; Vol. 14, No. SUPPL. 1. pp. 33-41.
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