The spread of drug-resistant tuberculosis in children: An Italian case series

F. Mignone, L. R. Codecasa, C. Scolfaro, I. Raffaldi, L. Lancella, M. Ferrarese, S. Garazzino, C. Marabotto, S. Esposito, C. Gabiano, R. Lipreri, P. A. Tovo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Drug-resistant paediatric tuberculosis (TB) is an overlooked global problem. In Italy, the epidemiology of TB has recently changed and data regarding drug-resistant forms in the paediatric setting is scanty. The aim of this case series was to report the cases of drug-resistant TB, diagnosed between June 2006 and July 2010 in four Italian tertiary centres for paediatric infectious diseases, in children and adolescents living in Italy. Twenty-two children were enrolled, of these 17 were resistant to one or more drugs and five had multidrug-resistant TB. All but one child were either foreign born or had at least one foreign parent. Twenty-one patients completed their treatment without clinical or radiological signs of activity at the end of treatment, and one patient was lost to follow up. The outcomes were good, with few adverse effects using second-line anti-TB drugs. Although this series is limited, it might already reflect the worrisome increase of drug-resistant TB, even in childhood.

Original languageEnglish
Pages (from-to)2049-2056
Number of pages8
JournalEpidemiology and Infection
Volume142
Issue number10
DOIs
Publication statusPublished - 2014

Fingerprint

Multidrug-Resistant Tuberculosis
Pediatrics
Italy
Tuberculosis
Pharmaceutical Preparations
Lost to Follow-Up
Communicable Diseases
Epidemiology
Therapeutics

Keywords

  • Adolescent
  • children
  • drug resistance
  • treatment
  • tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology

Cite this

Mignone, F., Codecasa, L. R., Scolfaro, C., Raffaldi, I., Lancella, L., Ferrarese, M., ... Tovo, P. A. (2014). The spread of drug-resistant tuberculosis in children: An Italian case series. Epidemiology and Infection, 142(10), 2049-2056. https://doi.org/10.1017/S0950268813003191

The spread of drug-resistant tuberculosis in children : An Italian case series. / Mignone, F.; Codecasa, L. R.; Scolfaro, C.; Raffaldi, I.; Lancella, L.; Ferrarese, M.; Garazzino, S.; Marabotto, C.; Esposito, S.; Gabiano, C.; Lipreri, R.; Tovo, P. A.

In: Epidemiology and Infection, Vol. 142, No. 10, 2014, p. 2049-2056.

Research output: Contribution to journalArticle

Mignone, F, Codecasa, LR, Scolfaro, C, Raffaldi, I, Lancella, L, Ferrarese, M, Garazzino, S, Marabotto, C, Esposito, S, Gabiano, C, Lipreri, R & Tovo, PA 2014, 'The spread of drug-resistant tuberculosis in children: An Italian case series', Epidemiology and Infection, vol. 142, no. 10, pp. 2049-2056. https://doi.org/10.1017/S0950268813003191
Mignone, F. ; Codecasa, L. R. ; Scolfaro, C. ; Raffaldi, I. ; Lancella, L. ; Ferrarese, M. ; Garazzino, S. ; Marabotto, C. ; Esposito, S. ; Gabiano, C. ; Lipreri, R. ; Tovo, P. A. / The spread of drug-resistant tuberculosis in children : An Italian case series. In: Epidemiology and Infection. 2014 ; Vol. 142, No. 10. pp. 2049-2056.
@article{5474d5b0dc5e4383af93db453fa7d96e,
title = "The spread of drug-resistant tuberculosis in children: An Italian case series",
abstract = "Drug-resistant paediatric tuberculosis (TB) is an overlooked global problem. In Italy, the epidemiology of TB has recently changed and data regarding drug-resistant forms in the paediatric setting is scanty. The aim of this case series was to report the cases of drug-resistant TB, diagnosed between June 2006 and July 2010 in four Italian tertiary centres for paediatric infectious diseases, in children and adolescents living in Italy. Twenty-two children were enrolled, of these 17 were resistant to one or more drugs and five had multidrug-resistant TB. All but one child were either foreign born or had at least one foreign parent. Twenty-one patients completed their treatment without clinical or radiological signs of activity at the end of treatment, and one patient was lost to follow up. The outcomes were good, with few adverse effects using second-line anti-TB drugs. Although this series is limited, it might already reflect the worrisome increase of drug-resistant TB, even in childhood.",
keywords = "Adolescent, children, drug resistance, treatment, tuberculosis",
author = "F. Mignone and Codecasa, {L. R.} and C. Scolfaro and I. Raffaldi and L. Lancella and M. Ferrarese and S. Garazzino and C. Marabotto and S. Esposito and C. Gabiano and R. Lipreri and Tovo, {P. A.}",
year = "2014",
doi = "10.1017/S0950268813003191",
language = "English",
volume = "142",
pages = "2049--2056",
journal = "Epidemiology and Infection",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "10",

}

TY - JOUR

T1 - The spread of drug-resistant tuberculosis in children

T2 - An Italian case series

AU - Mignone, F.

AU - Codecasa, L. R.

AU - Scolfaro, C.

AU - Raffaldi, I.

AU - Lancella, L.

AU - Ferrarese, M.

AU - Garazzino, S.

AU - Marabotto, C.

AU - Esposito, S.

AU - Gabiano, C.

AU - Lipreri, R.

AU - Tovo, P. A.

PY - 2014

Y1 - 2014

N2 - Drug-resistant paediatric tuberculosis (TB) is an overlooked global problem. In Italy, the epidemiology of TB has recently changed and data regarding drug-resistant forms in the paediatric setting is scanty. The aim of this case series was to report the cases of drug-resistant TB, diagnosed between June 2006 and July 2010 in four Italian tertiary centres for paediatric infectious diseases, in children and adolescents living in Italy. Twenty-two children were enrolled, of these 17 were resistant to one or more drugs and five had multidrug-resistant TB. All but one child were either foreign born or had at least one foreign parent. Twenty-one patients completed their treatment without clinical or radiological signs of activity at the end of treatment, and one patient was lost to follow up. The outcomes were good, with few adverse effects using second-line anti-TB drugs. Although this series is limited, it might already reflect the worrisome increase of drug-resistant TB, even in childhood.

AB - Drug-resistant paediatric tuberculosis (TB) is an overlooked global problem. In Italy, the epidemiology of TB has recently changed and data regarding drug-resistant forms in the paediatric setting is scanty. The aim of this case series was to report the cases of drug-resistant TB, diagnosed between June 2006 and July 2010 in four Italian tertiary centres for paediatric infectious diseases, in children and adolescents living in Italy. Twenty-two children were enrolled, of these 17 were resistant to one or more drugs and five had multidrug-resistant TB. All but one child were either foreign born or had at least one foreign parent. Twenty-one patients completed their treatment without clinical or radiological signs of activity at the end of treatment, and one patient was lost to follow up. The outcomes were good, with few adverse effects using second-line anti-TB drugs. Although this series is limited, it might already reflect the worrisome increase of drug-resistant TB, even in childhood.

KW - Adolescent

KW - children

KW - drug resistance

KW - treatment

KW - tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=84906274578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906274578&partnerID=8YFLogxK

U2 - 10.1017/S0950268813003191

DO - 10.1017/S0950268813003191

M3 - Article

C2 - 24480079

AN - SCOPUS:84906274578

VL - 142

SP - 2049

EP - 2056

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 10

ER -