The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism

Tommaso Bovi, Angelo Antonini, Sarah Ottaviani, Angela Antonioli, Maria Paola Cecchini, Vincenzo Di Francesco, Maria Antonietta Bassetto, Mauro Zamboni, Antonio Fiaschi, Giuseppe Moretto, Andrea Sbarbati, Michele Tinazzi, Francesco Osculati

Research output: Contribution to journalArticle

Abstract

Olfactory impairment has been reported in drug-induced parkinsonism (DIP), but the relationship between dopaminergic dysfunction and smell deficits in DIP patients has not been characterized. To this end, we studied 16 DIP patients and 13 patients affected by Parkinson's disease (PD) using the "Sniffin' Sticks" test and [123I] FP-CIT SPECT (single-photon emission computed tomography). DIP patients were divided based on normal (n = 9) and abnormal (n = 7) putamen dopamine transporter binding. Nineteen healthy age- and sex-matched subjects served as controls of smell function. Patients with DIP and pathological putamen uptake had abnormal olfactory function. In this group of patients, olfactory TDI scores (odor threshold, discrimination and identification) correlated significantly with putamen uptake values, as observed in PD patients. By contrast, DIP patients with normal putamen uptake showed odor functions - with the exception of the threshold subtest - similar to control subjects. In this group of patients, no significant correlation was observed between olfactory TDI scores and putamen uptake values. The results of our study suggest that the presence of smell deficits in DIP patients might be more associated with dopaminergic loss rather than with a drug-mediated dopamine receptor blockade. These preliminary results might have prognostic and therapeutic implications, as abnormalities in these individuals may be suggestive of an underlying PD-like neurodegenerative process.

Original languageEnglish
Pages (from-to)1882-1889
Number of pages8
JournalJournal of Neurology
Volume257
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Corpus Striatum
Parkinsonian Disorders
Putamen
Pharmaceutical Preparations
Smell
Parkinson Disease
Dopamine Plasma Membrane Transport Proteins
Dopamine Receptors
Single-Photon Emission-Computed Tomography

Keywords

  • [ I] FP-CIT SPECT
  • Parkinson's disease drug-induced parkinsonism
  • Sniffin' sticks test

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Bovi, T., Antonini, A., Ottaviani, S., Antonioli, A., Cecchini, M. P., Di Francesco, V., ... Osculati, F. (2010). The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism. Journal of Neurology, 257(11), 1882-1889. https://doi.org/10.1007/s00415-010-5631-3

The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism. / Bovi, Tommaso; Antonini, Angelo; Ottaviani, Sarah; Antonioli, Angela; Cecchini, Maria Paola; Di Francesco, Vincenzo; Bassetto, Maria Antonietta; Zamboni, Mauro; Fiaschi, Antonio; Moretto, Giuseppe; Sbarbati, Andrea; Tinazzi, Michele; Osculati, Francesco.

In: Journal of Neurology, Vol. 257, No. 11, 11.2010, p. 1882-1889.

Research output: Contribution to journalArticle

Bovi, T, Antonini, A, Ottaviani, S, Antonioli, A, Cecchini, MP, Di Francesco, V, Bassetto, MA, Zamboni, M, Fiaschi, A, Moretto, G, Sbarbati, A, Tinazzi, M & Osculati, F 2010, 'The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism', Journal of Neurology, vol. 257, no. 11, pp. 1882-1889. https://doi.org/10.1007/s00415-010-5631-3
Bovi T, Antonini A, Ottaviani S, Antonioli A, Cecchini MP, Di Francesco V et al. The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism. Journal of Neurology. 2010 Nov;257(11):1882-1889. https://doi.org/10.1007/s00415-010-5631-3
Bovi, Tommaso ; Antonini, Angelo ; Ottaviani, Sarah ; Antonioli, Angela ; Cecchini, Maria Paola ; Di Francesco, Vincenzo ; Bassetto, Maria Antonietta ; Zamboni, Mauro ; Fiaschi, Antonio ; Moretto, Giuseppe ; Sbarbati, Andrea ; Tinazzi, Michele ; Osculati, Francesco. / The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism. In: Journal of Neurology. 2010 ; Vol. 257, No. 11. pp. 1882-1889.
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