The stem cell hypothesis in head and neck cancer

A. Graziano, R. D'Aquino, V. Tirino, V. Desiderio, A. Rossi, G. Pirozzi

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Cancer stem cells (CSCs) are tumoral cells which have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. In the last 10 years the pathological meaning and the existence of CSCs have been matter of discussion and a large number of articles have been published about the role that these cells play in the development and maintenance of the tumors. Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide: early diagnosis of high-risk premalignant lesions are high priorities for reducing deaths due to head and neck cancer. In the last years the CSCs hypothesis has been faced also for head and neck cancer, with the aim of a better comprehension of the tumor biology and an early diagnosis. The evidence that the development of a tumor comes from a small number of cells with stem-like characteristic, could bring too to the identification of therapies against these cellular target, fundamental for maintenance and progression of the lesion. Here, a literature review has been reported about the detection of supposed CSCs in head and neck cancer.

Original languageEnglish
Pages (from-to)408-412
Number of pages5
JournalJournal of Cellular Biochemistry
Volume103
Issue number2
DOIs
Publication statusPublished - Feb 1 2008

Fingerprint

Neoplastic Stem Cells
Head and Neck Neoplasms
Stem cells
Stem Cells
Tumors
Maintenance
Neoplasms
Aptitude
Early Detection of Cancer
Drug Resistance
Early Diagnosis
Cell Count
Pharmaceutical Preparations
Therapeutics

Keywords

  • Cancer
  • Stem cell

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Graziano, A., D'Aquino, R., Tirino, V., Desiderio, V., Rossi, A., & Pirozzi, G. (2008). The stem cell hypothesis in head and neck cancer. Journal of Cellular Biochemistry, 103(2), 408-412. https://doi.org/10.1002/jcb.21436

The stem cell hypothesis in head and neck cancer. / Graziano, A.; D'Aquino, R.; Tirino, V.; Desiderio, V.; Rossi, A.; Pirozzi, G.

In: Journal of Cellular Biochemistry, Vol. 103, No. 2, 01.02.2008, p. 408-412.

Research output: Contribution to journalArticle

Graziano, A, D'Aquino, R, Tirino, V, Desiderio, V, Rossi, A & Pirozzi, G 2008, 'The stem cell hypothesis in head and neck cancer', Journal of Cellular Biochemistry, vol. 103, no. 2, pp. 408-412. https://doi.org/10.1002/jcb.21436
Graziano A, D'Aquino R, Tirino V, Desiderio V, Rossi A, Pirozzi G. The stem cell hypothesis in head and neck cancer. Journal of Cellular Biochemistry. 2008 Feb 1;103(2):408-412. https://doi.org/10.1002/jcb.21436
Graziano, A. ; D'Aquino, R. ; Tirino, V. ; Desiderio, V. ; Rossi, A. ; Pirozzi, G. / The stem cell hypothesis in head and neck cancer. In: Journal of Cellular Biochemistry. 2008 ; Vol. 103, No. 2. pp. 408-412.
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