The stem cell secretome and its role in brain repair

Denise Drago, Chiara Cossetti, Nunzio Iraci, Edoardo Gaude, Giovanna Musco, Angela Bachi, Stefano Pluchino

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal (MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and therapeutic effect after transplantation in experimental central nervous system (CNS) disease models through the secretion of immune modulatory or neurotrophic paracrine factors. This paracrine hypothesis has inspired an alternative outlook on the use of stem cells in regenerative neurology. In this paradigm, significant repair of the injured brain may be achieved by injecting the biologics secreted by stem cells (secretome), rather than implanting stem cells themselves for direct cell replacement. The stem cell secretome (SCS) includes cytokines, chemokines and growth factors, and has gained increasing attention in recent years because of its multiple implications for the repair, restoration or regeneration of injured tissues. Thanks to recent improvements in SCS profiling and manipulation, investigators are now inspired to harness the SCS as a novel alternative therapeutic option that might ensure more efficient outcomes than current stem cell-based therapies for CNS repair. This review discusses the most recent identification of MSC- and NPC-secreted factors, including those that are trafficked within extracellular membrane vesicles (EVs), and reflects on their potential effects on brain repair. It also examines some of the most convincing advances in molecular profiling that have enabled mapping of the SCS.

Original languageEnglish
Pages (from-to)2271-2285
Number of pages15
JournalBiochimie
Volume95
Issue number12
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Stem cells
Brain
Repair
Stem Cells
Neurology
Neural Stem Cells
Stem Cell Factor
Central Nervous System Diseases
Nerve Growth Factors
Therapeutic Uses
Cell- and Tissue-Based Therapy
Biological Products
Mesenchymal Stromal Cells
Chemokines
Regeneration
Intercellular Signaling Peptides and Proteins
Restoration
Central Nervous System
Transplantation
Research Personnel

Keywords

  • Brain repair
  • Mesenchymal stem cells
  • Neural stem cells
  • Secretome
  • Stem cell transplantation

ASJC Scopus subject areas

  • Biochemistry

Cite this

Drago, D., Cossetti, C., Iraci, N., Gaude, E., Musco, G., Bachi, A., & Pluchino, S. (2013). The stem cell secretome and its role in brain repair. Biochimie, 95(12), 2271-2285. https://doi.org/10.1016/j.biochi.2013.06.020

The stem cell secretome and its role in brain repair. / Drago, Denise; Cossetti, Chiara; Iraci, Nunzio; Gaude, Edoardo; Musco, Giovanna; Bachi, Angela; Pluchino, Stefano.

In: Biochimie, Vol. 95, No. 12, 12.2013, p. 2271-2285.

Research output: Contribution to journalArticle

Drago, D, Cossetti, C, Iraci, N, Gaude, E, Musco, G, Bachi, A & Pluchino, S 2013, 'The stem cell secretome and its role in brain repair', Biochimie, vol. 95, no. 12, pp. 2271-2285. https://doi.org/10.1016/j.biochi.2013.06.020
Drago D, Cossetti C, Iraci N, Gaude E, Musco G, Bachi A et al. The stem cell secretome and its role in brain repair. Biochimie. 2013 Dec;95(12):2271-2285. https://doi.org/10.1016/j.biochi.2013.06.020
Drago, Denise ; Cossetti, Chiara ; Iraci, Nunzio ; Gaude, Edoardo ; Musco, Giovanna ; Bachi, Angela ; Pluchino, Stefano. / The stem cell secretome and its role in brain repair. In: Biochimie. 2013 ; Vol. 95, No. 12. pp. 2271-2285.
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