The stomach cancer pooling (StoP) project: Study design and presentation

Claudio Pelucchi, Nuno Lunet, Stefania Boccia, Zuo Feng Zhang, Delphine Praud, Paolo Boffetta, Fabio Levi, Keitaro Matsuo, Hidemi Ito, Jinfu Hu, Kenneth C. Johnson, Monica Ferraroni, Guo Pei Yu, Bárbara Peleteiro, Reza Malekzadeh, Mohammad H. Derakhshan, Weimin Ye, David Zaridze, Dmitry Maximovitch, Nuria AragonésVicente Martín, Mohammadreza Pakseresht, Farhad Pourfarzi, Andrea Bellavia, Nicola Orsini, Alicja Wolk, Lina Mu, Dario Arzani, Robert C. Kurtz, Pagona Lagiou, Dimitrios Trichopoulos, Joshua Muscat, Carlo La Vecchia, Eva Negri

Research output: Contribution to journalArticle

Abstract

Gastric cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The study of its etiology remains therefore a global issue as it may allow the identification of major targets, besides eradication of Helicobacter pylori infection, for primary prevention. It has however received little attention, given its comparatively low incidence in most high-income countries. We introduce a consortium of epidemiological investigations named the 'Stomach cancer Pooling (StoP) Project'. Twenty-two studies agreed to participate, for a total of over 9000 cases and 23 000 controls. Twenty studies have already shared the original data set. Of the patients, 40% are from Asia, 43% from Europe, and 17% from North America; 34% are women and 66% men; the median age is 61 years; 56% are from population-based case-control studies, 41% from hospital-based ones, and 3% from nested case-control studies derived from cohort investigations. Biological samples are available from 12 studies. The aim of the StoP Project is to analyze the role of lifestyle and genetic determinants in the etiology of gastric cancer through pooled analyses of individual-level data. The uniquely large data set will allow us to define and quantify the main effects of each risk factor of interest, including a number of infrequent habits, and to adequately address associations in subgroups of the population, as well as interaction within and between environmental and genetic factors. Further, we will carry out separate analyses according to different histotypes and subsites of gastric cancer, to identify potential different risk patterns and etiological characteristics.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalEuropean Journal of Cancer Prevention
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 11 2015

Fingerprint

Stomach Neoplasms
Case-Control Studies
Helicobacter Infections
Primary Prevention
North America
Helicobacter pylori
Population
Habits
Life Style
Mortality
Incidence
Neoplasms
Datasets

Keywords

  • consortia
  • epidemiology
  • pooled analysis
  • risk factors
  • stomach neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

The stomach cancer pooling (StoP) project : Study design and presentation. / Pelucchi, Claudio; Lunet, Nuno; Boccia, Stefania; Zhang, Zuo Feng; Praud, Delphine; Boffetta, Paolo; Levi, Fabio; Matsuo, Keitaro; Ito, Hidemi; Hu, Jinfu; Johnson, Kenneth C.; Ferraroni, Monica; Yu, Guo Pei; Peleteiro, Bárbara; Malekzadeh, Reza; Derakhshan, Mohammad H.; Ye, Weimin; Zaridze, David; Maximovitch, Dmitry; Aragonés, Nuria; Martín, Vicente; Pakseresht, Mohammadreza; Pourfarzi, Farhad; Bellavia, Andrea; Orsini, Nicola; Wolk, Alicja; Mu, Lina; Arzani, Dario; Kurtz, Robert C.; Lagiou, Pagona; Trichopoulos, Dimitrios; Muscat, Joshua; La Vecchia, Carlo; Negri, Eva.

In: European Journal of Cancer Prevention, Vol. 24, No. 1, 11.01.2015, p. 16-23.

Research output: Contribution to journalArticle

Pelucchi, C, Lunet, N, Boccia, S, Zhang, ZF, Praud, D, Boffetta, P, Levi, F, Matsuo, K, Ito, H, Hu, J, Johnson, KC, Ferraroni, M, Yu, GP, Peleteiro, B, Malekzadeh, R, Derakhshan, MH, Ye, W, Zaridze, D, Maximovitch, D, Aragonés, N, Martín, V, Pakseresht, M, Pourfarzi, F, Bellavia, A, Orsini, N, Wolk, A, Mu, L, Arzani, D, Kurtz, RC, Lagiou, P, Trichopoulos, D, Muscat, J, La Vecchia, C & Negri, E 2015, 'The stomach cancer pooling (StoP) project: Study design and presentation', European Journal of Cancer Prevention, vol. 24, no. 1, pp. 16-23. https://doi.org/10.1097/CEJ.0000000000000017
Pelucchi, Claudio ; Lunet, Nuno ; Boccia, Stefania ; Zhang, Zuo Feng ; Praud, Delphine ; Boffetta, Paolo ; Levi, Fabio ; Matsuo, Keitaro ; Ito, Hidemi ; Hu, Jinfu ; Johnson, Kenneth C. ; Ferraroni, Monica ; Yu, Guo Pei ; Peleteiro, Bárbara ; Malekzadeh, Reza ; Derakhshan, Mohammad H. ; Ye, Weimin ; Zaridze, David ; Maximovitch, Dmitry ; Aragonés, Nuria ; Martín, Vicente ; Pakseresht, Mohammadreza ; Pourfarzi, Farhad ; Bellavia, Andrea ; Orsini, Nicola ; Wolk, Alicja ; Mu, Lina ; Arzani, Dario ; Kurtz, Robert C. ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Muscat, Joshua ; La Vecchia, Carlo ; Negri, Eva. / The stomach cancer pooling (StoP) project : Study design and presentation. In: European Journal of Cancer Prevention. 2015 ; Vol. 24, No. 1. pp. 16-23.
@article{a55d912e228a48fc9e24686ff3b7ff2b,
title = "The stomach cancer pooling (StoP) project: Study design and presentation",
abstract = "Gastric cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The study of its etiology remains therefore a global issue as it may allow the identification of major targets, besides eradication of Helicobacter pylori infection, for primary prevention. It has however received little attention, given its comparatively low incidence in most high-income countries. We introduce a consortium of epidemiological investigations named the 'Stomach cancer Pooling (StoP) Project'. Twenty-two studies agreed to participate, for a total of over 9000 cases and 23 000 controls. Twenty studies have already shared the original data set. Of the patients, 40{\%} are from Asia, 43{\%} from Europe, and 17{\%} from North America; 34{\%} are women and 66{\%} men; the median age is 61 years; 56{\%} are from population-based case-control studies, 41{\%} from hospital-based ones, and 3{\%} from nested case-control studies derived from cohort investigations. Biological samples are available from 12 studies. The aim of the StoP Project is to analyze the role of lifestyle and genetic determinants in the etiology of gastric cancer through pooled analyses of individual-level data. The uniquely large data set will allow us to define and quantify the main effects of each risk factor of interest, including a number of infrequent habits, and to adequately address associations in subgroups of the population, as well as interaction within and between environmental and genetic factors. Further, we will carry out separate analyses according to different histotypes and subsites of gastric cancer, to identify potential different risk patterns and etiological characteristics.",
keywords = "consortia, epidemiology, pooled analysis, risk factors, stomach neoplasms",
author = "Claudio Pelucchi and Nuno Lunet and Stefania Boccia and Zhang, {Zuo Feng} and Delphine Praud and Paolo Boffetta and Fabio Levi and Keitaro Matsuo and Hidemi Ito and Jinfu Hu and Johnson, {Kenneth C.} and Monica Ferraroni and Yu, {Guo Pei} and B{\'a}rbara Peleteiro and Reza Malekzadeh and Derakhshan, {Mohammad H.} and Weimin Ye and David Zaridze and Dmitry Maximovitch and Nuria Aragon{\'e}s and Vicente Mart{\'i}n and Mohammadreza Pakseresht and Farhad Pourfarzi and Andrea Bellavia and Nicola Orsini and Alicja Wolk and Lina Mu and Dario Arzani and Kurtz, {Robert C.} and Pagona Lagiou and Dimitrios Trichopoulos and Joshua Muscat and {La Vecchia}, Carlo and Eva Negri",
year = "2015",
month = "1",
day = "11",
doi = "10.1097/CEJ.0000000000000017",
language = "English",
volume = "24",
pages = "16--23",
journal = "European Journal of Cancer Prevention",
issn = "0959-8278",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - The stomach cancer pooling (StoP) project

T2 - Study design and presentation

AU - Pelucchi, Claudio

AU - Lunet, Nuno

AU - Boccia, Stefania

AU - Zhang, Zuo Feng

AU - Praud, Delphine

AU - Boffetta, Paolo

AU - Levi, Fabio

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Hu, Jinfu

AU - Johnson, Kenneth C.

AU - Ferraroni, Monica

AU - Yu, Guo Pei

AU - Peleteiro, Bárbara

AU - Malekzadeh, Reza

AU - Derakhshan, Mohammad H.

AU - Ye, Weimin

AU - Zaridze, David

AU - Maximovitch, Dmitry

AU - Aragonés, Nuria

AU - Martín, Vicente

AU - Pakseresht, Mohammadreza

AU - Pourfarzi, Farhad

AU - Bellavia, Andrea

AU - Orsini, Nicola

AU - Wolk, Alicja

AU - Mu, Lina

AU - Arzani, Dario

AU - Kurtz, Robert C.

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Muscat, Joshua

AU - La Vecchia, Carlo

AU - Negri, Eva

PY - 2015/1/11

Y1 - 2015/1/11

N2 - Gastric cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The study of its etiology remains therefore a global issue as it may allow the identification of major targets, besides eradication of Helicobacter pylori infection, for primary prevention. It has however received little attention, given its comparatively low incidence in most high-income countries. We introduce a consortium of epidemiological investigations named the 'Stomach cancer Pooling (StoP) Project'. Twenty-two studies agreed to participate, for a total of over 9000 cases and 23 000 controls. Twenty studies have already shared the original data set. Of the patients, 40% are from Asia, 43% from Europe, and 17% from North America; 34% are women and 66% men; the median age is 61 years; 56% are from population-based case-control studies, 41% from hospital-based ones, and 3% from nested case-control studies derived from cohort investigations. Biological samples are available from 12 studies. The aim of the StoP Project is to analyze the role of lifestyle and genetic determinants in the etiology of gastric cancer through pooled analyses of individual-level data. The uniquely large data set will allow us to define and quantify the main effects of each risk factor of interest, including a number of infrequent habits, and to adequately address associations in subgroups of the population, as well as interaction within and between environmental and genetic factors. Further, we will carry out separate analyses according to different histotypes and subsites of gastric cancer, to identify potential different risk patterns and etiological characteristics.

AB - Gastric cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The study of its etiology remains therefore a global issue as it may allow the identification of major targets, besides eradication of Helicobacter pylori infection, for primary prevention. It has however received little attention, given its comparatively low incidence in most high-income countries. We introduce a consortium of epidemiological investigations named the 'Stomach cancer Pooling (StoP) Project'. Twenty-two studies agreed to participate, for a total of over 9000 cases and 23 000 controls. Twenty studies have already shared the original data set. Of the patients, 40% are from Asia, 43% from Europe, and 17% from North America; 34% are women and 66% men; the median age is 61 years; 56% are from population-based case-control studies, 41% from hospital-based ones, and 3% from nested case-control studies derived from cohort investigations. Biological samples are available from 12 studies. The aim of the StoP Project is to analyze the role of lifestyle and genetic determinants in the etiology of gastric cancer through pooled analyses of individual-level data. The uniquely large data set will allow us to define and quantify the main effects of each risk factor of interest, including a number of infrequent habits, and to adequately address associations in subgroups of the population, as well as interaction within and between environmental and genetic factors. Further, we will carry out separate analyses according to different histotypes and subsites of gastric cancer, to identify potential different risk patterns and etiological characteristics.

KW - consortia

KW - epidemiology

KW - pooled analysis

KW - risk factors

KW - stomach neoplasms

UR - http://www.scopus.com/inward/record.url?scp=84916878769&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916878769&partnerID=8YFLogxK

U2 - 10.1097/CEJ.0000000000000017

DO - 10.1097/CEJ.0000000000000017

M3 - Article

C2 - 24566154

AN - SCOPUS:84916878769

VL - 24

SP - 16

EP - 23

JO - European Journal of Cancer Prevention

JF - European Journal of Cancer Prevention

SN - 0959-8278

IS - 1

ER -