TY - JOUR
T1 - The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors.
AU - Gaddi, Antonio Vittorino
AU - Capello, Fabio
AU - Aluigi, Leonardo
AU - Antignani, Pier Luigi
AU - Callegaro, Annapaola
AU - Casu, Gavino
AU - Cipolla, Enrico
AU - Cipolla, Maurizio
AU - Cosco, Lucio
AU - Culzoni, Federico
AU - Dentali, Francesco
AU - Elexpuru-Zabaleta, Maria
AU - Forbes-Hernandez, Tamara Y
AU - Fragiacomo, Claudia
AU - Giampieri, Francesca
AU - Gnasso, Agostino
AU - Mancini, Raffaele
AU - Modena, Maria Grazia
AU - Nichelatti, Michele
AU - Paradiso, Angelo Virgilio
AU - Ortasi, Pasquale
AU - Savo, Maria Teresa
AU - Tangianu, Flavio
AU - Tempesta, Sergio
AU - Voci, Tommaso Diego
AU - Battino, Maurizio
PY - 2020/6/22
Y1 - 2020/6/22
N2 - Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for epidemiologic one. The right equilibrium between high speed, low cost and accuracy is obtained with easy-to-use decentralized point-of-care test as the colloidal gold-based immunochromatographic strip assay which detects IgM and IgG antibodies directed against SARS-CoV-2. As our aim is to evaluate the efficacy of Covid-19 rapid tests and of serological assays in real-life settings, we designed a research protocol aimed to establish how to use correctly these diagnostics, taking into account the different possible clinical and epidemiological scenarios.
AB - Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for epidemiologic one. The right equilibrium between high speed, low cost and accuracy is obtained with easy-to-use decentralized point-of-care test as the colloidal gold-based immunochromatographic strip assay which detects IgM and IgG antibodies directed against SARS-CoV-2. As our aim is to evaluate the efficacy of Covid-19 rapid tests and of serological assays in real-life settings, we designed a research protocol aimed to establish how to use correctly these diagnostics, taking into account the different possible clinical and epidemiological scenarios.
KW - COVID-19
KW - COVID-19 Testing
KW - Clinical Laboratory Techniques/methods
KW - Coronavirus Infections/diagnosis
KW - Humans
KW - Mass Screening/methods
KW - Pandemics/prevention & control
KW - Pneumonia, Viral/epidemiology
KW - Practice Guidelines as Topic
KW - Primary Prevention/methods
U2 - 10.3390/ijms21124446
DO - 10.3390/ijms21124446
M3 - Review article
C2 - 32580529
VL - 21
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 12
M1 - 4446
ER -