The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors.

Antonio Vittorino Gaddi, Fabio Capello, Leonardo Aluigi, Pier Luigi Antignani, Annapaola Callegaro, Gavino Casu, Enrico Cipolla, Maurizio Cipolla, Lucio Cosco, Federico Culzoni, Francesco Dentali, Maria Elexpuru-Zabaleta, Tamara Y Forbes-Hernandez, Claudia Fragiacomo, Francesca Giampieri, Agostino Gnasso, Raffaele Mancini, Maria Grazia Modena, Michele Nichelatti, Angelo Virgilio ParadisoPasquale Ortasi, Maria Teresa Savo, Flavio Tangianu, Sergio Tempesta, Tommaso Diego Voci, Maurizio Battino

Research output: Contribution to journalReview articlepeer-review

Abstract

Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for epidemiologic one. The right equilibrium between high speed, low cost and accuracy is obtained with easy-to-use decentralized point-of-care test as the colloidal gold-based immunochromatographic strip assay which detects IgM and IgG antibodies directed against SARS-CoV-2. As our aim is to evaluate the efficacy of Covid-19 rapid tests and of serological assays in real-life settings, we designed a research protocol aimed to establish how to use correctly these diagnostics, taking into account the different possible clinical and epidemiological scenarios.

Original languageEnglish
Article number4446
JournalInternational Journal of Molecular Sciences
Volume21
Issue number12
DOIs
Publication statusPublished - Jun 22 2020

Keywords

  • COVID-19
  • COVID-19 Testing
  • Clinical Laboratory Techniques/methods
  • Coronavirus Infections/diagnosis
  • Humans
  • Mass Screening/methods
  • Pandemics/prevention & control
  • Pneumonia, Viral/epidemiology
  • Practice Guidelines as Topic
  • Primary Prevention/methods

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