The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors.

Antonio Vittorino Gaddi; Fabio Capello; Leonardo Aluigi; Pier Luigi Antignani; Annapaola Callegaro; Gavino Casu; Enrico Cipolla; Maurizio Cipolla; Lucio Cosco; Federico Culzoni; Francesco Dentali; Maria Elexpuru-Zabaleta; Tamara Y Forbes-Hernandez; Claudia Fragiacomo; Francesca Giampieri; Agostino Gnasso; Raffaele Mancini; Maria Grazia Modena; Michele Nichelatti; Angelo Virgilio Paradiso; Pasquale Ortasi; Maria Teresa Savo; Flavio Tangianu; Sergio Tempesta; Tommaso Diego Voci; Maurizio Battino

doi:10.3390/ijms21124446

The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors.

Antonio Vittorino Gaddi, Fabio Capello, Leonardo Aluigi, Pier Luigi Antignani, Annapaola Callegaro, Gavino Casu, Enrico Cipolla, Maurizio Cipolla, Lucio Cosco, Federico Culzoni, Francesco Dentali, Maria Elexpuru-Zabaleta, Tamara Y Forbes-Hernandez, Claudia Fragiacomo, Francesca Giampieri, Agostino Gnasso, Raffaele Mancini, Maria Grazia Modena, Michele Nichelatti, Angelo Virgilio ParadisoPasquale Ortasi, Maria Teresa Savo, Flavio Tangianu, Sergio Tempesta, Tommaso Diego Voci, Maurizio Battino

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Review article › peer-review

Abstract

Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for epidemiologic one. The right equilibrium between high speed, low cost and accuracy is obtained with easy-to-use decentralized point-of-care test as the colloidal gold-based immunochromatographic strip assay which detects IgM and IgG antibodies directed against SARS-CoV-2. As our aim is to evaluate the efficacy of Covid-19 rapid tests and of serological assays in real-life settings, we designed a research protocol aimed to establish how to use correctly these diagnostics, taking into account the different possible clinical and epidemiological scenarios.

Original language	English
Article number	4446
Journal	International Journal of Molecular Sciences
Volume	21
Issue number	12
DOIs	https://doi.org/10.3390/ijms21124446
Publication status	Published - Jun 22 2020

Keywords

COVID-19
COVID-19 Testing
Clinical Laboratory Techniques/methods
Coronavirus Infections/diagnosis
Humans
Mass Screening/methods
Pandemics/prevention & control
Pneumonia, Viral/epidemiology
Practice Guidelines as Topic
Primary Prevention/methods

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10.3390/ijms21124446

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Gaddi, A. V., Capello, F., Aluigi, L., Antignani, P. L., Callegaro, A., Casu, G., Cipolla, E., Cipolla, M., Cosco, L., Culzoni, F., Dentali, F., Elexpuru-Zabaleta, M., Forbes-Hernandez, T. Y., Fragiacomo, C., Giampieri, F., Gnasso, A., Mancini, R., Modena, M. G., Nichelatti, M., ... Battino, M. (2020). The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors. International Journal of Molecular Sciences, 21(12), [4446]. https://doi.org/10.3390/ijms21124446

The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors. / Gaddi, Antonio Vittorino; Capello, Fabio; Aluigi, Leonardo; Antignani, Pier Luigi; Callegaro, Annapaola; Casu, Gavino; Cipolla, Enrico; Cipolla, Maurizio; Cosco, Lucio; Culzoni, Federico; Dentali, Francesco; Elexpuru-Zabaleta, Maria; Forbes-Hernandez, Tamara Y; Fragiacomo, Claudia; Giampieri, Francesca; Gnasso, Agostino; Mancini, Raffaele; Modena, Maria Grazia; Nichelatti, Michele; Paradiso, Angelo Virgilio; Ortasi, Pasquale; Savo, Maria Teresa; Tangianu, Flavio; Tempesta, Sergio; Voci, Tommaso Diego; Battino, Maurizio.

In: International Journal of Molecular Sciences, Vol. 21, No. 12, 4446, 22.06.2020.

Research output: Contribution to journal › Review article › peer-review

Gaddi, AV, Capello, F, Aluigi, L, Antignani, PL, Callegaro, A, Casu, G, Cipolla, E, Cipolla, M, Cosco, L, Culzoni, F, Dentali, F, Elexpuru-Zabaleta, M, Forbes-Hernandez, TY, Fragiacomo, C, Giampieri, F, Gnasso, A, Mancini, R, Modena, MG, Nichelatti, M, Paradiso, AV, Ortasi, P, Savo, MT, Tangianu, F, Tempesta, S, Voci, TD & Battino, M 2020, 'The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors.', International Journal of Molecular Sciences, vol. 21, no. 12, 4446. https://doi.org/10.3390/ijms21124446

Gaddi, Antonio Vittorino ; Capello, Fabio ; Aluigi, Leonardo ; Antignani, Pier Luigi ; Callegaro, Annapaola ; Casu, Gavino ; Cipolla, Enrico ; Cipolla, Maurizio ; Cosco, Lucio ; Culzoni, Federico ; Dentali, Francesco ; Elexpuru-Zabaleta, Maria ; Forbes-Hernandez, Tamara Y ; Fragiacomo, Claudia ; Giampieri, Francesca ; Gnasso, Agostino ; Mancini, Raffaele ; Modena, Maria Grazia ; Nichelatti, Michele ; Paradiso, Angelo Virgilio ; Ortasi, Pasquale ; Savo, Maria Teresa ; Tangianu, Flavio ; Tempesta, Sergio ; Voci, Tommaso Diego ; Battino, Maurizio. / The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors. In: International Journal of Molecular Sciences. 2020 ; Vol. 21, No. 12.

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abstract = "Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for epidemiologic one. The right equilibrium between high speed, low cost and accuracy is obtained with easy-to-use decentralized point-of-care test as the colloidal gold-based immunochromatographic strip assay which detects IgM and IgG antibodies directed against SARS-CoV-2. As our aim is to evaluate the efficacy of Covid-19 rapid tests and of serological assays in real-life settings, we designed a research protocol aimed to establish how to use correctly these diagnostics, taking into account the different possible clinical and epidemiological scenarios.",

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AU - Antignani, Pier Luigi

AU - Callegaro, Annapaola

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AU - Paradiso, Angelo Virgilio

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AU - Voci, Tommaso Diego

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KW - Pneumonia, Viral/epidemiology

KW - Practice Guidelines as Topic

KW - Primary Prevention/methods

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The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors.

Abstract

Keywords

Access to Document

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