The structural perspective on CDK5

Marina Mapelli, Andrea Musacchio

Research output: Contribution to journalArticle

Abstract

Cyclin-dependent kinase 5 (CDK5) plays an essential role in the development of the central nervous system during mammalian embryogenesis. In the adult, CDK5 is required for the maintenance of neuronal architecture. Its deregulation has profound cytotoxic effects and has been implicated in the development of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. In this review, we concentrate on the regulation of CDK5 activity, privileging a structural perspective based on a decade of structural analyses of different members of the CDK family, including CDK2 and CDK5. We review the activation mechanism of CDK5 and discuss its differences and similarities with that of CDK2 and of the other members of the CDK family.

Original languageEnglish
Pages (from-to)164-172
Number of pages9
JournalNeuroSignals
Volume12
Issue number4-5
DOIs
Publication statusPublished - 2003

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Keywords

  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Cyclin-dependent kinase 2
  • Cyclin-dependent kinase 5
  • Neuronal cyclin-dependent kinase 5 activator
  • p25
  • p35
  • p39

ASJC Scopus subject areas

  • Neuroscience(all)

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