The structure of the vascular network of tumors

Domenico Ribatti, Beatrice Nico, Enrico Crivellato, Angelo Vacca

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Tumor blood vessels display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels and markedly heterogeneous density. This review will focus on the factors influencing this heterogeneity.

Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalCancer Letters
Volume248
Issue number1
DOIs
Publication statusPublished - Apr 8 2007

Fingerprint

Blood Vessels
Vascular Tissue Neoplasms
Tumor Microenvironment
Growth
Basement Membrane
Neoplasms
Endothelial Cells

Keywords

  • Angiogenesis
  • Endothelium
  • Microvasculature
  • Tumor

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Ribatti, D., Nico, B., Crivellato, E., & Vacca, A. (2007). The structure of the vascular network of tumors. Cancer Letters, 248(1), 18-23. https://doi.org/10.1016/j.canlet.2006.06.007

The structure of the vascular network of tumors. / Ribatti, Domenico; Nico, Beatrice; Crivellato, Enrico; Vacca, Angelo.

In: Cancer Letters, Vol. 248, No. 1, 08.04.2007, p. 18-23.

Research output: Contribution to journalArticle

Ribatti, D, Nico, B, Crivellato, E & Vacca, A 2007, 'The structure of the vascular network of tumors', Cancer Letters, vol. 248, no. 1, pp. 18-23. https://doi.org/10.1016/j.canlet.2006.06.007
Ribatti D, Nico B, Crivellato E, Vacca A. The structure of the vascular network of tumors. Cancer Letters. 2007 Apr 8;248(1):18-23. https://doi.org/10.1016/j.canlet.2006.06.007
Ribatti, Domenico ; Nico, Beatrice ; Crivellato, Enrico ; Vacca, Angelo. / The structure of the vascular network of tumors. In: Cancer Letters. 2007 ; Vol. 248, No. 1. pp. 18-23.
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