The subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia?

Harutomo Hasegawa, Richard Selway, Valentina Gnoni, Sandor Beniczky, Steve C.R. Williams, Meir Kryger, Luigi Ferini-Strambi, Peter Goadsby, Guy D. Leschziner, Keyoumars Ashkan, Ivana Rosenzweig

Research output: Contribution to journalReview articlepeer-review

Abstract

Early studies posited a relationship between sleep and the basal ganglia, but this relationship has received little attention recently. It is timely to revisit this relationship, given new insights into the functional anatomy of the basal ganglia and the physiology of sleep, which has been made possible by modern techniques such as chemogenetic and optogenetic mapping of neural circuits in rodents and intracranial recording, functional imaging, and a better understanding of human sleep disorders. We discuss the functional anatomy of the basal ganglia, and review evidence implicating their role in sleep. Whilst these studies are in their infancy, we suggest that the basal ganglia may play an integral role in the sleep-wake cycle, specifically by contributing to a thalamo-cortical-basal ganglia oscillatory network in slow-wave sleep which facilitates neural plasticity, and an active state during REM sleep which enables the enactment of cognitive and emotional networks. A better understanding of sleep mechanisms may pave the way for more effective neuromodulation strategies for sleep and basal ganglia disorders.

Original languageEnglish
Article number101317
JournalSleep Medicine Reviews
Volume52
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Basal ganglia
  • Memory
  • Neuromodulation
  • Sleep

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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