Abstract
To test a new tool for the neurophysiological identification of the human subthalamic nucleus (STN) during stereotactic surgery for the implantation of deep-brain-stimulation (DBS) electrodes, we analysed off-line the intraoperative signals recorded from patients with Parkinson's disease. We estimated the power spectral density (PSD) along each penetration track (8 patients, 13 sides) and determined the spatial correlation of the PSD with the target location estimated from neuroimaging procedures ("anatomical target"), and with the final target location derived from standard intraoperative neurophysiological procedures for STN localization ("clinical target"). At each step we recorded the 'on-line' signal for 120 seconds; because the PSD was estimated by calculating the periodogram for 6-second epochs of neural signal, we had 20 epochs at each step. When the electrode track crossed the STN, the PSD in the 0.25-2.5 kHz band increased, peaking on average
| Original language | English |
|---|---|
| Pages (from-to) | 367-374 |
| Number of pages | 8 |
| Journal | Neurological Sciences |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Feb 2004 |
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Keywords
- Deep brain stimulation
- Intraoperative monitoring
- Neurophysiology
- Parkinson's disease
- Power spectral density analysis
- Subthalamic nucleus
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
The subthalamic nucleus in Parkinson's disease : Power spectral density analysis of neural intraoperative signals. / Presenti, A.; Rohr, M.; Egidi, M.; Rampini, P.; Tamma, F.; Locatelli, M.; Caputo, E.; Chiesa, V.; Bianchi, A.; Barbieri, S.; Baselli, G.; Priori, Alberto.
In: Neurological Sciences, Vol. 24, No. 6, 02.2004, p. 367-374.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The subthalamic nucleus in Parkinson's disease
T2 - Power spectral density analysis of neural intraoperative signals
AU - Presenti, A.
AU - Rohr, M.
AU - Egidi, M.
AU - Rampini, P.
AU - Tamma, F.
AU - Locatelli, M.
AU - Caputo, E.
AU - Chiesa, V.
AU - Bianchi, A.
AU - Barbieri, S.
AU - Baselli, G.
AU - Priori, Alberto
PY - 2004/2
Y1 - 2004/2
N2 - To test a new tool for the neurophysiological identification of the human subthalamic nucleus (STN) during stereotactic surgery for the implantation of deep-brain-stimulation (DBS) electrodes, we analysed off-line the intraoperative signals recorded from patients with Parkinson's disease. We estimated the power spectral density (PSD) along each penetration track (8 patients, 13 sides) and determined the spatial correlation of the PSD with the target location estimated from neuroimaging procedures ("anatomical target"), and with the final target location derived from standard intraoperative neurophysiological procedures for STN localization ("clinical target"). At each step we recorded the 'on-line' signal for 120 seconds; because the PSD was estimated by calculating the periodogram for 6-second epochs of neural signal, we had 20 epochs at each step. When the electrode track crossed the STN, the PSD in the 0.25-2.5 kHz band increased, peaking on average
AB - To test a new tool for the neurophysiological identification of the human subthalamic nucleus (STN) during stereotactic surgery for the implantation of deep-brain-stimulation (DBS) electrodes, we analysed off-line the intraoperative signals recorded from patients with Parkinson's disease. We estimated the power spectral density (PSD) along each penetration track (8 patients, 13 sides) and determined the spatial correlation of the PSD with the target location estimated from neuroimaging procedures ("anatomical target"), and with the final target location derived from standard intraoperative neurophysiological procedures for STN localization ("clinical target"). At each step we recorded the 'on-line' signal for 120 seconds; because the PSD was estimated by calculating the periodogram for 6-second epochs of neural signal, we had 20 epochs at each step. When the electrode track crossed the STN, the PSD in the 0.25-2.5 kHz band increased, peaking on average
KW - Deep brain stimulation
KW - Intraoperative monitoring
KW - Neurophysiology
KW - Parkinson's disease
KW - Power spectral density analysis
KW - Subthalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=10744222226&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744222226&partnerID=8YFLogxK
U2 - 10.1007/s10072-003-0191-2
DO - 10.1007/s10072-003-0191-2
M3 - Article
C2 - 14767681
AN - SCOPUS:10744222226
VL - 24
SP - 367
EP - 374
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -