The subthalamic nucleus in Parkinson's disease: Power spectral density analysis of neural intraoperative signals

A. Presenti, M. Rohr, M. Egidi, P. Rampini, F. Tamma, M. Locatelli, E. Caputo, V. Chiesa, A. Bianchi, S. Barbieri, G. Baselli, Alberto Priori

Research output: Contribution to journalArticle

Abstract

To test a new tool for the neurophysiological identification of the human subthalamic nucleus (STN) during stereotactic surgery for the implantation of deep-brain-stimulation (DBS) electrodes, we analysed off-line the intraoperative signals recorded from patients with Parkinson's disease. We estimated the power spectral density (PSD) along each penetration track (8 patients, 13 sides) and determined the spatial correlation of the PSD with the target location estimated from neuroimaging procedures ("anatomical target"), and with the final target location derived from standard intraoperative neurophysiological procedures for STN localization ("clinical target"). At each step we recorded the 'on-line' signal for 120 seconds; because the PSD was estimated by calculating the periodogram for 6-second epochs of neural signal, we had 20 epochs at each step. When the electrode track crossed the STN, the PSD in the 0.25-2.5 kHz band increased, peaking on average

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalNeurological Sciences
Volume24
Issue number6
DOIs
Publication statusPublished - Feb 2004

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Subthalamic Nucleus
Parkinson Disease
Electrodes
Forensic Anthropology
Deep Brain Stimulation
Neuroimaging

Keywords

  • Deep brain stimulation
  • Intraoperative monitoring
  • Neurophysiology
  • Parkinson's disease
  • Power spectral density analysis
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

The subthalamic nucleus in Parkinson's disease : Power spectral density analysis of neural intraoperative signals. / Presenti, A.; Rohr, M.; Egidi, M.; Rampini, P.; Tamma, F.; Locatelli, M.; Caputo, E.; Chiesa, V.; Bianchi, A.; Barbieri, S.; Baselli, G.; Priori, Alberto.

In: Neurological Sciences, Vol. 24, No. 6, 02.2004, p. 367-374.

Research output: Contribution to journalArticle

Presenti, A, Rohr, M, Egidi, M, Rampini, P, Tamma, F, Locatelli, M, Caputo, E, Chiesa, V, Bianchi, A, Barbieri, S, Baselli, G & Priori, A 2004, 'The subthalamic nucleus in Parkinson's disease: Power spectral density analysis of neural intraoperative signals', Neurological Sciences, vol. 24, no. 6, pp. 367-374. https://doi.org/10.1007/s10072-003-0191-2
Presenti, A. ; Rohr, M. ; Egidi, M. ; Rampini, P. ; Tamma, F. ; Locatelli, M. ; Caputo, E. ; Chiesa, V. ; Bianchi, A. ; Barbieri, S. ; Baselli, G. ; Priori, Alberto. / The subthalamic nucleus in Parkinson's disease : Power spectral density analysis of neural intraoperative signals. In: Neurological Sciences. 2004 ; Vol. 24, No. 6. pp. 367-374.
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