The suicide gene therapy challenge: How to improve a successful gene therapy approach

Chiara Bonini, Attilio Bondanza, Serena Kimi Perna, Shin Kaneko, Catia Traversari, Fabio Ciceri, Claudio Bordignon

Research output: Contribution to journalArticle

Abstract

The transfer of a suicide gene into donor lymphocytes to control alloreactivity in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the widest clinical application of T-cell based gene transfer, as shown by more than 100 patients treated worldwide to date, several phase I-II studies completed, and a registrative phase III study, sponsored by a biotech firm, about to begin. In this mini-review, we will summarize the clinical results obtained to date, and attempt to identify the steps envisaged to optimize the suicide gene therapy approach.

Original languageEnglish
Pages (from-to)1248-1252
Number of pages5
JournalMolecular Therapy
Volume15
Issue number7
DOIs
Publication statusPublished - Jul 2007

ASJC Scopus subject areas

  • Molecular Biology

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