The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections

Domenico Mattoscio; Chiara Casadio; Marzia Fumagalli; Mario Sideri; Susanna Chiocca

doi:10.3332/ecancer.2015.534

The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections

Domenico Mattoscio, Chiara Casadio, Marzia Fumagalli, Mario Sideri, Susanna Chiocca

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Human papillomaviruses (HPVs) infect stratified epithelium and are the causative agents of cervical cancer, the second most common cause of cancer-related death in women. A critical aspect that still persists in the HPV field is the selection of very sensitive and specific HPV diagnostic assays. Here, we provide evidence that the crucial small ubiquitin-like modifier (SUMO) E2-conjugating enzyme Ubc9 is strongly upregulated in cervical lesions. Ubc9 detection could thus be used in diagnosing and/or monitoring the progression of an HPV oncogenic infection.

Original language	English
Article number	534
Journal	ecancermedicalscience
Volume	9
DOIs	https://doi.org/10.3332/ecancer.2015.534
Publication status	Published - Apr 29 2015

Keywords

Biomarker
Cervical cancer
HPV
HSIL
LSIL
SUMO
Ubc9

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3332/ecancer.2015.534

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abstract = "Human papillomaviruses (HPVs) infect stratified epithelium and are the causative agents of cervical cancer, the second most common cause of cancer-related death in women. A critical aspect that still persists in the HPV field is the selection of very sensitive and specific HPV diagnostic assays. Here, we provide evidence that the crucial small ubiquitin-like modifier (SUMO) E2-conjugating enzyme Ubc9 is strongly upregulated in cervical lesions. Ubc9 detection could thus be used in diagnosing and/or monitoring the progression of an HPV oncogenic infection.",

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AU - Chiocca, Susanna

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AB - Human papillomaviruses (HPVs) infect stratified epithelium and are the causative agents of cervical cancer, the second most common cause of cancer-related death in women. A critical aspect that still persists in the HPV field is the selection of very sensitive and specific HPV diagnostic assays. Here, we provide evidence that the crucial small ubiquitin-like modifier (SUMO) E2-conjugating enzyme Ubc9 is strongly upregulated in cervical lesions. Ubc9 detection could thus be used in diagnosing and/or monitoring the progression of an HPV oncogenic infection.

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The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections

Abstract

Keywords

ASJC Scopus subject areas

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