Abstract
Human papillomaviruses (HPVs) infect stratified epithelium and are the causative agents of cervical cancer, the second most common cause of cancer-related death in women. A critical aspect that still persists in the HPV field is the selection of very sensitive and specific HPV diagnostic assays. Here, we provide evidence that the crucial small ubiquitin-like modifier (SUMO) E2-conjugating enzyme Ubc9 is strongly upregulated in cervical lesions. Ubc9 detection could thus be used in diagnosing and/or monitoring the progression of an HPV oncogenic infection.
Original language | English |
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Article number | 534 |
Journal | ecancermedicalscience |
Volume | 9 |
DOIs | |
Publication status | Published - Apr 29 2015 |
Keywords
- Biomarker
- Cervical cancer
- HPV
- HSIL
- LSIL
- SUMO
- Ubc9
ASJC Scopus subject areas
- Oncology
- Cancer Research